| Gene Symbol | Rangap1 |
|---|---|
| Entrez Gene | 19387 |
| Alt Symbol | C79654, Fug1, mKIAA1835 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | RAN GTPase activating protein 1 |
| Other Description | ran GTPase-activating protein 1 |
| Swissprots | Q60801 P46061 Q6NZB5 |
| Accessions | AAB60517 EDL04560 EDL04561 EDL04562 P46061 AK005370 BAB23979 AK035571 AK042930 AK088768 BAC40559 AK129452 BAC98262 AK133905 BAE21919 AK145459 BAE26449 AK146670 BAE27347 AK159009 BAE34767 AK159525 BAE35154 AK159930 AK177694 AK178591 AK178655 AK179009 AK179704 AK181740 AK183983 AK186071 AK205227 AK205795 AK206461 AK209217 AK211293 AK211773 AK213698 AK214151 AK214243 BC014855 AAH14855 BC052862 AAH52862 BC066213 AAH66213 BC071200 AAH71200 BY287991 BY438103 U08110 AAA17681 XM_006520646 XP_006520709 XM_011245524 XP_011243826 XR_383994 NM_001146174 NP_001139646 NM_011241 NP_035371 |
| Function | GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for postimplantation development. {ECO:0000269|PubMed:16469311, ECO:0000269|PubMed:9442102, ECO:0000269|PubMed:9456312}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation (By similarity). {ECO:0000250}. |
| Top Pathways | RNA transport |