Gene Symbol | GNG10 |
---|---|
Entrez Gene | 2790 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | guanine nucleotide binding protein (G protein), gamma 10 |
Other Description | guanine nucleotide binding protein 10|guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 |
Swissprots | P50151 Q3B7K2 Q4VC27 |
Accessions | EAW59079 EAW59080 EAW59083 EAW59087 P50151 AF493877 AAM12591 AW583403 BC010384 AAH10384 BC015206 BC016319 AAH16319 BC072671 AAH72671 BC107574 AAI07575 BG708408 DB504443 HQ447946 ADQ32430 U31383 AAC50205 NM_001017998 NP_001017998 NM_001198664 NP_001185593 |
Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Interacts with beta-1 and beta-2, but not with beta-3. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
Tissue Specificity | Abundantly and ubiquitously expressed. |
Top Pathways | Dopaminergic synapse, Morphine addiction, Glutamatergic synapse, PI3K-Akt signaling pathway, GABAergic synapse |