Gene Symbol | GNG10 |
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Entrez Gene | 2790 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | guanine nucleotide binding protein (G protein), gamma 10 |
Other Description | guanine nucleotide binding protein 10|guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 |
Swissprots | P50151 Q3B7K2 Q4VC27 |
Accessions | EAW59079 EAW59080 EAW59083 EAW59087 P50151 AF493877 AAM12591 AW583403 BC010384 AAH10384 BC015206 BC016319 AAH16319 BC072671 AAH72671 BC107574 AAI07575 BG708408 DB504443 HQ447946 ADQ32430 U31383 AAC50205 NM_001017998 NP_001017998 NM_001198664 NP_001185593 |
Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Interacts with beta-1 and beta-2, but not with beta-3. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
Tissue Specificity | Abundantly and ubiquitously expressed. |
Top Pathways | Dopaminergic synapse, Morphine addiction, Glutamatergic synapse, PI3K-Akt signaling pathway, GABAergic synapse |
Gγ 10 CRISPR/Cas9 KO Plasmid (h) - sc-417858 from Santa Cruz Biotechnology
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Gγ 10 HDR Plasmid (h) - sc-417858-HDR from Santa Cruz Biotechnology
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Gγ 10 Double Nickase Plasmid (h) - sc-417858-NIC from Santa Cruz Biotechnology
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Gγ 10 Double Nickase Plasmid (h2) - sc-417858-NIC-2 from Santa Cruz Biotechnology
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Gγ 10 CRISPR Activation Plasmid (h) - sc-417858-ACT from Santa Cruz Biotechnology
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Gγ 10 CRISPR Activation Plasmid (h2) - sc-417858-ACT-2 from Santa Cruz Biotechnology
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Gγ 10 Lentiviral Activation Particles (h) - sc-417858-LAC from Santa Cruz Biotechnology
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Gγ 10 Lentiviral Activation Particles (h2) - sc-417858-LAC-2 from Santa Cruz Biotechnology
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G γ 10 siRNA (h) - sc-41784 from Santa Cruz Biotechnology
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G γ 10 shRNA Plasmid (h) - sc-41784-SH from Santa Cruz Biotechnology
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G γ 10 shRNA (h) Lentiviral Particles - sc-41784-V from Santa Cruz Biotechnology
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GNG10 RNAi - H00002790-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9423 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9423 from Sigma-Aldrich
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GNG10 siRNA (Human) - CRH1861 from Cohesion Biosciences
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GNG10 - MBS8227073 from MyBioSource
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shRNA set against Human Gng10 (NM_001017998.3) - SHH304842 from Creative biogene
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Human GNG10 siRNA - orb262363 from Biorbyt
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GNG10 shRNA Plasmid (Human) - CHH1861 from Cohesion Biosciences
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GNG10 miRNA 3'UTR clone - MiUTR3H-06766 from Creative biogene
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