FZD7

Gene Symbol	FZD7
Entrez Gene	8324
Alt Symbol	FzE3
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 7
Other Description	Frizzled, drosophila, homolog of, 7|frizzled 7, seven transmembrane spanning receptor|frizzled family receptor 7|frizzled homolog 7|frizzled-7|fz-7|hFz7
Swissprots	O94816 Q53S59 Q96B74 O75084
Accessions	AAX93250 EAW70298 O75084 AB010881 BAA32424 AB017365 BAA34668 BC015915 AAH15915 JF432234 ADZ15451 NM_003507 NP_003498
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular Location	Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

frizzled-7 (D-13) - sc-31061 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

frizzled-7 (F-13) - sc-31063 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

frizzled-7 (G-13) - sc-31060 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Frizzled 7 antibody - ab115214 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Frizzled 7 antibody - ab177081 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (aa33-185) - LS-C6915 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (Biotin) - LS-C6917 from LifeSpan Bioscience Prices $650.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-FZD7 / Frizzled 7 Antibody - LS-C6916 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-FZD7 / Frizzled 7 Antibody (Extracellular Domain) - LS-C6918 from LifeSpan Bioscience Prices $575.00 Sizes 500 µg Host Rat Clonality Monoclonal

Anti-FZD7 / Frizzled 7 Antibody (aa33-185, Biotin) - LS-C6919 from LifeSpan Bioscience Prices $650.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (aa1-12) - LS-C40593 from LifeSpan Bioscience Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (aa1-12) - LS-C23705 from LifeSpan Bioscience Prices $325.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (aa560-573) - LS-C147917 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (C-Terminus) - LS-C30350 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (C-Terminus) - LS-C210104 from LifeSpan Bioscience Prices $295.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (aa33-185) - LS-C150195 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (Internal) - LS-C210105 from LifeSpan Bioscience Prices $295.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (aa201-230, AP) - LS-C214435 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (aa201-230, APC) - LS-C214436 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (aa201-230, Biotin) - LS-C214437 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody (aa201-230, Azide-free, HRP) - LS-C214438 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody - LS-C178785 from LifeSpan Bioscience Prices $385.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-FZD7 / Frizzled 7 Antibody (Tyr87) - LS-C177186 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FZD7 / Frizzled 7 Antibody - LS-C178786 from LifeSpan Bioscience Prices $385.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-FZD7 / Frizzled 7 Antibody (aa45-94) - LS-C120598 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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