| Gene Symbol | FZD7 |
|---|---|
| Entrez Gene | 8324 |
| Alt Symbol | FzE3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 7 |
| Other Description | Frizzled, drosophila, homolog of, 7|frizzled 7, seven transmembrane spanning receptor|frizzled family receptor 7|frizzled homolog 7|frizzled-7|fz-7|hFz7 |
| Swissprots | O94816 Q53S59 Q96B74 O75084 |
| Accessions | AAX93250 EAW70298 O75084 AB010881 BAA32424 AB017365 BAA34668 BC015915 AAH15915 JF432234 ADZ15451 NM_003507 NP_003498 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Subcellular Location | Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
frizzled-7 CRISPR/Cas9 KO Plasmid (h) - sc-401590 from Santa Cruz Biotechnology
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frizzled-7 HDR Plasmid (h) - sc-401590-HDR from Santa Cruz Biotechnology
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frizzled-7 Double Nickase Plasmid (h) - sc-401590-NIC from Santa Cruz Biotechnology
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frizzled-7 Double Nickase Plasmid (h2) - sc-401590-NIC-2 from Santa Cruz Biotechnology
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frizzled-7 CRISPR Activation Plasmid (h) - sc-401590-ACT from Santa Cruz Biotechnology
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frizzled-7 CRISPR Activation Plasmid (h2) - sc-401590-ACT-2 from Santa Cruz Biotechnology
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frizzled-7 Lentiviral Activation Particles (h) - sc-401590-LAC from Santa Cruz Biotechnology
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frizzled-7 Lentiviral Activation Particles (h2) - sc-401590-LAC-2 from Santa Cruz Biotechnology
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frizzled-7 siRNA (h) - sc-39990 from Santa Cruz Biotechnology
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frizzled-7 shRNA Plasmid (h) - sc-39990-SH from Santa Cruz Biotechnology
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frizzled-7 shRNA (h) Lentiviral Particles - sc-39990-V from Santa Cruz Biotechnology
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Frizzled-7 RNAi - H00008324-R02 from Novus Biologicals
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MISSION® esiRNA - EHU121641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2161 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11049 from Sigma-Aldrich
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FZD7 siRNA (Human) - CRH5446 from Cohesion Biosciences
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FZD7 - MBS8236824 from MyBioSource
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shRNA set against Human FZD7 (NM_003507.1) - SHH298133 from Creative biogene
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shRNA set against Human FZD7(NM_003507.1) - SHH072317 from Creative biogene
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FZD7 shRNA Plasmid (Human) - CHH5446 from Cohesion Biosciences
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FZD7 miRNA 3'UTR clone - MiUTR1H-03891 from Creative biogene
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