| Gene Symbol |
UBE4A
|
| Entrez Gene |
9354
|
| Alt Symbol |
E4, UBOX2, UFD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitination factor E4A
|
| Other Description |
ubiquitin conjugation factor E4 A|ubiquitination factor E4A (UFD2 homolog, yeast)
|
| Swissprots |
B0YJB6 Q7Z639 Q2M1H0 Q14139 Q6P5T4
|
| Accessions |
ACA06094 CCQ43280 EAW67371 EAW67372 Q14139 AF087968 AK296369 BAG59044 AK302328 BAH13676 AK307737 AL713515 AW021567 AW290969 BC010938 BC030973 AAH30973 BC039240 BC052643 AAH52643 BC062695 AAH62695 BC111417 AAI11418 BC112367 AAI12368 BU167020 D50916 BAA09475 DB068702 NM_001204077 NP_001191006 NM_004788 NP_004779
|
| Function |
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:E9Q735}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|