COPS5

Gene Symbol	COPS5
Entrez Gene	10987
Alt Symbol	CSN5, JAB1, MOV-34, SGN5
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 5
Other Description	38 kDa Mov34 homolog|COP9 constitutive photomorphogenic homolog subunit 5|COP9 signalosome complex subunit 5|jun activation domain-binding protein 1|signalosome subunit 5
Swissprots	Q9BQ17 Q86WQ4 O15386 Q92905 Q6AW95
Accessions	CBH51784 EAW86928 EAW86929 EAW86930 EAW86931 Q92905 AA203444 AB209134 BAD92371 AK056967 AK128519 AK310434 AK311071 BC001187 AAH01187 BC001859 AAH01859 BC007272 AAH07272 BI752436 BX648542 CAH10375 CR541678 CAG46479 JF432439 ADZ15656 U65928 AAB16847 U70734 AAD03468 NM_006837 NP_006828
Function	Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key rol
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Nuclear localization is diminished in the presence of IFIT3.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human JAB1 full length protein - ab131744 from Abcam Category Protein Source Wheat germ Species Human

Human JAB1 protein fragment - ab92007 from Abcam Category Protein Source E. coli Species Human

COPS5 / JAB1 Antibody Blocking Peptide - LS-E11555 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COPS5 / JAB1 Antibody Blocking Peptide - LS-E11015 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human JAB1 Protein - H00010987-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

COPS5-Antibody-C-term-Blocking-Peptide - BP8911b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

COPS5-Antibody-C-term-Blocking-Peptide - BP8867b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JAB1 Blocking Peptide - abx063717 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey, Pig, Zebrafish

COPS5 - H00010987-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

COPS5 - H00010987-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

JAB1 fusion protein - Ag0126 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human COPS5, His-tagged - COPS5-29878TH from Creative Biomart Category Protein Source E. coli

Recombinant Human JAB1, GST-tagged - JAB1-198H from Creative Biomart Category Protein Source E.coli Species Human

JAB1 Blocking Peptide - CBP2523 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Pig, Zebrafish

COPS5 / JAB1 (K191) Peptide - BS2340P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human COP9 signalosome complex subunit 5(COPS5) - CSB-YP821714HU CSB-EP821714HU CSB-BP821714HU CSB-MP821714HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

COPS5 - TP300979 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human COPS5 protein, His-tagged - COPS5-40H from Creative Biomart Category Protein Source E.coli Species Human

JAB1 Recombinant Protein Antigen - NBP1-84370PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

COPS5-Blocking-Peptide-Center - BP21563c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

COPS5 Peptide, Human - M34GP03502H from Creative Peptides Category Peptide Source Synthetic. Species Human

JAB1 fusion protein - Ag25956 from Proteintech Group Category Protein Source E. coli -derived, PET30a Species Human

JAB1 Recombinant Protein Antigen - NBP2-55578PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

COP9 signalosome complex subunit 5 (COPS5), Recombinant Protein - MBS1354747 from MyBioSource Category Protein Prices $1,095.00, $1,095.00, $1,325.00, $1,325.00, $1,725.00, $1,725.00, $2,190.00, $2,190.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

COP9 signalosome complex subunit 5 (csn5), Recombinant Protein - MBS1474349 from MyBioSource Category Protein Prices $1,095.00, $1,095.00, $1,325.00, $1,325.00, $1,725.00, $1,725.00, $2,190.00, $2,190.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Neosartorya

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