Gene Symbol | Dhfr |
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Entrez Gene | 13361 |
Alt Symbol | 8430436I03Rik, AA607882, AI662710, AW555094 |
Species | Mouse |
Gene Type | protein-coding |
Description | dihydrofolate reductase |
Other Description | - |
Swissprots | Q61485 P00375 Q61579 P70693 Q61487 |
Accessions | AAA37637 AAA37638 AAO26057 CAA24111 CAP58632 CAX23887 EDL00958 P00375 AI854085 AK018462 AK031241 BAC27315 AK136212 BAE22879 BC005796 AAH05796 BU058996 CB247191 L26316 AAA37523 M10722 AAA37524 M10811 AAA37525 V00731 CAB43539 V00732 V00734 CAA24112 X56066 CAA39544 NM_010049 NP_034179 |
Function | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. |
Top Pathways | Folate biosynthesis, One carbon pool by folate |
DHFR CRISPR/Cas9 KO Plasmid (m) - sc-419998 from Santa Cruz Biotechnology
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DHFR HDR Plasmid (m) - sc-419998-HDR from Santa Cruz Biotechnology
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DHFR Double Nickase Plasmid (m) - sc-419998-NIC from Santa Cruz Biotechnology
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DHFR Double Nickase Plasmid (m2) - sc-419998-NIC-2 from Santa Cruz Biotechnology
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DHFR CRISPR Activation Plasmid (m) - sc-419998-ACT from Santa Cruz Biotechnology
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DHFR CRISPR Activation Plasmid (m2) - sc-419998-ACT-2 from Santa Cruz Biotechnology
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DHFR Lentiviral Activation Particles (m) - sc-419998-LAC from Santa Cruz Biotechnology
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DHFR Lentiviral Activation Particles (m2) - sc-419998-LAC-2 from Santa Cruz Biotechnology
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DHFR siRNA (m) - sc-37079 from Santa Cruz Biotechnology
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DHFR shRNA Plasmid (m) - sc-37079-SH from Santa Cruz Biotechnology
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DHFR shRNA (m) Lentiviral Particles - sc-37079-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU070791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN29958 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29958 from Sigma-Aldrich
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DHFR siRNA (Mouse) - CRM1025 from Cohesion Biosciences
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DHFR - MBS8235036 from MyBioSource
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shRNA set against Mouse DHFR (NM_010049.3) - SHH277617 from Creative biogene
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shRNA set against Mouse Dhfr(NM_010049.3) - SHH003521 from Creative biogene
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Mouse DHFR siRNA - orb280501 from Biorbyt
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DHFR shRNA Plasmid (Mouse) - CHM1025 from Cohesion Biosciences
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DHFR miRNA 3'UTR clone - MiUTR1M-03837 from Creative biogene
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