COPE
| Gene Symbol | COPE |
|---|---|
| Entrez Gene | 11316 |
| Alt Symbol | epsilon-COP |
| Species | Human |
| Gene Type | protein-coding |
| Description | coatomer protein complex, subunit epsilon |
| Other Description | coatomer epsilon subunit|coatomer subunit epsilon|epsilon coat protein|epsilon-coat protein |
| Swissprots | Q6IBB8 A6NKA3 A6NE29 Q9UGP6 O76097 O14579 |
| Accessions | AAB81543 AAC24612 CBX84922 CBX84941 EAW84748 EAW84749 EAW84750 EAW84751 EAW84752 EAW84753 EAW84754 EAW84755 EAW84756 EAW84757 O14579 AF092438 AAP97213 AI680336 AJ131182 CAA10316 AJ249366 CAB55628 AK023303 AK222584 BAD96304 AK315281 BAG37690 AL136928 CAB66862 AM393761 CAL38636 BC003155 AAH03155 BC007250 AAH07250 BC017285 AAH17285 BC052619 BI520280 CR456886 CAG33167 DQ893417 ABM84343 DQ896735 ABM87734 XM_011527655 XP_011525957 XM_011527656 XP_011525958 NM_007263 NP_009194 NM_199442 NP_955474 NM_199444 NP_955476 |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}. |
COPE CRISPR/Cas9 KO Plasmid (h) - sc-404151 from Santa Cruz Biotechnology
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COPE HDR Plasmid (h) - sc-404151-HDR from Santa Cruz Biotechnology
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COPE Double Nickase Plasmid (h) - sc-404151-NIC from Santa Cruz Biotechnology
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COPE Double Nickase Plasmid (h2) - sc-404151-NIC-2 from Santa Cruz Biotechnology
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COPE CRISPR Activation Plasmid (h) - sc-404151-ACT from Santa Cruz Biotechnology
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COPE CRISPR Activation Plasmid (h2) - sc-404151-ACT-2 from Santa Cruz Biotechnology
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COPE Lentiviral Activation Particles (h) - sc-404151-LAC from Santa Cruz Biotechnology
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COPE Lentiviral Activation Particles (h2) - sc-404151-LAC-2 from Santa Cruz Biotechnology
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COPE siRNA (h) - sc-41198 from Santa Cruz Biotechnology
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COPE shRNA Plasmid (h) - sc-41198-SH from Santa Cruz Biotechnology
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COPE shRNA (h) Lentiviral Particles - sc-41198-V from Santa Cruz Biotechnology
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COPE RNAi - H00011316-R02 from Novus Biologicals
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COPE RNAi - H00011316-R01 from Novus Biologicals
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MISSION® esiRNA - EHU069701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6428 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6428 from Sigma-Aldrich
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COPE siRNA (Human) - CRH7746 from Cohesion Biosciences
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COPE RNAi - H00011316-R03 from Novus Biologicals
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COPE - MBS8215488 from MyBioSource
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shRNA set against Human COPE (NM_007263.3) - SHH267761 from Creative biogene
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shRNA set against Human COPE(NM_199444.1) - SHG192421 from Creative biogene
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shRNA set against Human COPE(NM_007263.3) - SHG192439 from Creative biogene
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shRNA set against Human COPE(NM_199442.1) - SHG192475 from Creative biogene
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Human COPE siRNA - orb268248 from Biorbyt
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COPE shRNA Plasmid (Human) - CHH7746 from Cohesion Biosciences
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