| Gene Symbol | KCNA2 |
|---|---|
| Entrez Gene | 3737 |
| Alt Symbol | HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, voltage gated shaker related subfamily A, member 2 |
| Other Description | potassium voltage-gated channel subfamily A member 2|potassium voltage-gated channel, shaker-related subfamily, member 2|voltage-gated K(+) channel HuKIV|voltage-gated potassium channel HBK5|voltage-gated potassium channel protein Kv1.2|voltage-gated potassium channel subunit Kv1.2 |
| Swissprots | A0A024R0D3 P16389 Q86XG6 A8K1Z6 |
| Accessions | EAW56455 EAW56456 P16389 AK290061 BAF82750 BC043564 AAH43564 BI907383 BM682747 L02752 AAA36141 XM_011541396 XP_011539698 XM_011541397 XP_011539699 XM_011541398 XP_011539700 XM_011541399 XP_011539701 XM_011541400 XP_011539702 NM_001204269 NP_001191198 NM_004974 NP_004965 |
| Function | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559, PubMed:20220134). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:11211111, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:20220134, ECO:0000269|PubMed:23769686, ECO:0000269|PubMed:8495559}; Multi- pass membrane protein {ECO:0000250|UniProtKB:P63142, ECO:0000305}. Membrane {ECO:0000250|UniProtKB:P63142}. Cell projection, axon {ECO:0000269|PubMed:16473933}. Cell junction, synapse {ECO:0000250|UniProtKB:P63142}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63142}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:P63142}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:P63141}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:P63141}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63141}. Note=KCNA2 by itself is detected both at the endoplasmic reticulum and at the cell membrane. Coexpression with KCNA4 or with beta subunits promotes expression at the cell membrane. Coexpression with KCNA1 inhibits cell surface expression. {ECO:0000250|UniProtKB:P63142}. |
| Tissue Specificity | Detected in brain cortex (PubMed:16473933). Detected in peroneal nerve in the juxtaparanodal regions of the node of Ranvier; expression is decreased in patients with diabetes mellitus that suffer from axonal neuropathy (PubMed:22649228). Detected in paranodal and juxtanodal zones in myelinated spinal cord (at protein level) (PubMed:11086297). {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:16473933, ECO:0000269|PubMed:22649228}. |