| Gene Symbol |
CDC14B
|
| Entrez Gene |
8555
|
| Alt Symbol |
CDC14B3, Cdc14B1, Cdc14B2, hCDC14B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell division cycle 14B
|
| Other Description |
CDC14 cell division cycle 14 homolog B|dual specificity protein phosphatase CDC14B
|
| Swissprots |
O43183 Q5JU08 B1AL32 O60730 O60729 A8MQ20 A6N5X8 B1AL31
|
| Accessions |
AAT70726 EAW92658 EAW92659 O60729 AF023158 AAB88293 AF064104 AAC16661 AF064105 AAC16662 AK126388 BAG54321 AK225361 BC050013 BC156666 AAI56667 DA943563 EF611343 ABR12627 XM_005252288 XP_005252345 XM_011519146 XP_011517448 XM_011519147 XP_011517449 XM_011519148 XP_011517450 XM_011519149 XP_011517451 XM_011519150 XP_011517452 XM_011519151 XP_011517453 XM_011519152 XP_011517454 XM_011519153 XP_011517455 XM_011519154 XP_011517456 XM_011519155 XP_011517457 XM_011519156 XP_011517458 XM_011519157 XP_011517459 XM_011519158 XP_011517460 XM_011519159 XP_011517461 XM_011519160 XP_011517462 XR_242602 XR_929864 XR_929865 XR_929866 XR_929867 XR_929868 NM_001077181 NP_001070649 NM_003671 NP_003662 NM_033331 NP_201588 NM_033332
|
| Function |
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:9367992}.
|
| Subcellular Location |
Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
|
| Top Pathways |
Cell cycle
|