Gene Symbol | GAD2 |
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Entrez Gene | 2572 |
Alt Symbol | GAD65 |
Species | Human |
Gene Type | protein-coding |
Description | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) |
Other Description | 65 kDa glutamic acid decarboxylase|GAD-65|Glutamate decarboxylase-2 (pancreas)|glutamate decarboxylase 2|glutamate decarboxylase 65 kDa isoform |
Swissprots | Q05329 Q9UD87 |
Accessions | AAP88040 EAW86101 EAW86102 EAW86103 EAW86104 Q05329 AJ251501 CAB62572 AK127375 BAC86947 BC029517 AAH29517 BC039038 BC047899 BC126327 AAI26328 BC126329 AAI26330 BI438818 BP392604 HQ258311 ADR83065 M74826 AAA58491 M81882 AAA62367 X69936 NM_000818 NP_000809 NM_001134366 NP_001127838 |
Function | Catalyzes the production of GABA. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:12356867}. Cytoplasmic vesicle {ECO:0000269|PubMed:12356867}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:12356867}; Lipid-anchor {ECO:0000269|PubMed:12356867}. Golgi apparatus membrane {ECO:0000269|PubMed:12356867}; Peripheral membrane protein {ECO:0000269|PubMed:12356867}; Cytoplasmic side {ECO:0000269|PubMed:12356867}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. |
Top Pathways | Type I diabetes mellitus, GABAergic synapse, Taurine and hypotaurine metabolism, Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism |
GAD-65 CRISPR/Cas9 KO Plasmid (h) - sc-402137 from Santa Cruz Biotechnology
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GAD-65 HDR Plasmid (h) - sc-402137-HDR from Santa Cruz Biotechnology
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GAD-65 Double Nickase Plasmid (h) - sc-402137-NIC from Santa Cruz Biotechnology
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GAD-65 Double Nickase Plasmid (h2) - sc-402137-NIC-2 from Santa Cruz Biotechnology
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GAD-65 CRISPR Activation Plasmid (h) - sc-402137-ACT from Santa Cruz Biotechnology
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GAD-65 CRISPR Activation Plasmid (h2) - sc-402137-ACT-2 from Santa Cruz Biotechnology
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GAD-65 Lentiviral Activation Particles (h) - sc-402137-LAC from Santa Cruz Biotechnology
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GAD-65 Lentiviral Activation Particles (h2) - sc-402137-LAC-2 from Santa Cruz Biotechnology
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GAD-65 siRNA (h) - sc-41964 from Santa Cruz Biotechnology
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GAD-65 shRNA Plasmid (h) - sc-41964-SH from Santa Cruz Biotechnology
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GAD-65 shRNA (h) Lentiviral Particles - sc-41964-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU018781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9061 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04811 from Sigma-Aldrich
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GAD2 siRNA (Human) - CRH1710 from Cohesion Biosciences
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GAD2 - MBS8202875 from MyBioSource
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Human GAD2 siRNA - orb262212 from Biorbyt
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GAD2 shRNA Plasmid (Human) - CHH1710 from Cohesion Biosciences
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GAD2 miRNA 3'UTR clone - MiUTR3H-00897 from Creative biogene
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GAD2 miRNA 3'UTR clone - MiUTR3H-00898 from Creative biogene
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