| Gene Symbol | SDHA |
|---|---|
| Entrez Gene | 6389 |
| Alt Symbol | CMD1GG, FP, PGL5, SDH1, SDH2, SDHF |
| Species | Human |
| Gene Type | protein-coding |
| Description | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) |
| Other Description | flavoprotein subunit of complex II|succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial|succinate dehydrogenase complex flavoprotein subunit |
| Swissprots | P31040 E9PBJ5 Q59GW8 A8K5J6 Q8IW48 B4DJ60 Q9UMY5 Q16395 |
| Accessions | AAB35332 AAD51006 EAW50982 EAW50983 EAW50984 P31040 AB208991 BAD92228 AK094879 BAG52946 AK131350 BAG54767 AK131478 AK225027 AK291311 BAF84000 AK295937 BAG58722 AK302524 BAG63797 BC001380 AAH01380 BC004328 BC041016 AAH41016 CA427314 D30648 BAA06332 DA160919 DQ402982 ABD77315 HY265959 L21936 AAA20683 XM_005248331 XP_005248388 XM_011514072 XP_011512374 XM_011514073 XP_011512375 XR_925638 NM_001294332 NP_001281261 NM_004168 NP_004159 |
| Function | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. {ECO:0000269|PubMed:20484225}. |
| Subcellular Location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| Top Pathways | Citrate cycle (TCA cycle), Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation |