TGFBR1

Gene Symbol	TGFBR1
Entrez Gene	7046
Alt Symbol	AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I
Species	Human
Gene Type	protein-coding
Description	transforming growth factor, beta receptor 1
Other Description	TGF-beta receptor type-1|activin A receptor type II-like kinase, 53kDa|activin A receptor type II-like protein kinase of 53kD|activin receptor-like kinase 5|serine/threonine-protein kinase receptor R4|transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)|transforming growth factor-beta receptor type I
Swissprots	Q6IR47 P36897 Q706C1 Q706C0
Accessions	AAC08998 AAD02042 AAR32097 ABD46753 ACZ58375 CAZ91468 EAW58905 EAW58906 P36897 AJ420419 AJ619019 CAF02096 AJ619020 CAF02097 AK002171 AK129793 AK302059 BAG63449 AK302234 BAG63588 AL117597 BC038347 BC056247 BC071181 AAH71181 BX648917 EF142853 ABO93068 EF142854 ABO93069 L11695 AAA16073 XM_005252150 XP_005252207 XM_011518948 XP_011517250 XM_011518949 XP_011517251 XM_011518950 XP_011517252 NM_001130916 NP_001124388 NM_001306210 NP_001293139 NM_004612 NP_004603
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
Tissue Specificity	Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, Colorectal cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TGFBR1 / ALK5 ELISA Kit (Sandwich ELISA) - LS-F4042 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.117 ng/ml Range 0.313-20 ng/ml

Mouse TGFBR1 / ALK5 ELISA Kit (Sandwich ELISA) - LS-F9232 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.313-20 ng/ml

Human TGFBR1 / ALK5 ELISA Kit (Sandwich ELISA) - LS-F12746 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.313-20 ng/ml

TGF-beta receptor type-1 (TGFBR1), Human, ELISA Kit - CSB-EL023451HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

TGF-beta receptor type-1, TGFBR1, Human, ELISA Kit - E8813h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.156-10 ng/mL

Transforming Growth Factor Beta Receptor I (TGFbR1), Human, ELISA Kit - SEA397Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.118ng/mL Range 0.312-20ng/mL

ELISA Kit for Transforming Growth Factor Beta Receptor I (TGFbR1) - SEA397Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.121ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Transforming Growth Factor Beta Receptor I (TGFbR1) - SEA397Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

TGF-beta receptor type-1, TGFBR1, ELISA Kit - MBS9306014 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TGF-beta receptor type-1, TGFBR1, ELISA Kit - MBS9306341 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/ml. Range 3.12 ng/ml - 100 ng/ml.

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS074759 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS072969 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS068153 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS072761 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS075601 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS050009 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS081766 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS087398 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS094828 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS084851 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS107911 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS067472 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS083352 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS096678 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transforming Growth Factor Beta Receptor I, ELISA Kit - MBS105146 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml Range 0.625 ng/ml - 20 ng/ml

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