TGFBR1

Gene Symbol	TGFBR1
Entrez Gene	7046
Alt Symbol	AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I
Species	Human
Gene Type	protein-coding
Description	transforming growth factor, beta receptor 1
Other Description	TGF-beta receptor type-1|activin A receptor type II-like kinase, 53kDa|activin A receptor type II-like protein kinase of 53kD|activin receptor-like kinase 5|serine/threonine-protein kinase receptor R4|transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)|transforming growth factor-beta receptor type I
Swissprots	Q6IR47 P36897 Q706C1 Q706C0
Accessions	AAC08998 AAD02042 AAR32097 ABD46753 ACZ58375 CAZ91468 EAW58905 EAW58906 P36897 AJ420419 AJ619019 CAF02096 AJ619020 CAF02097 AK002171 AK129793 AK302059 BAG63449 AK302234 BAG63588 AL117597 BC038347 BC056247 BC071181 AAH71181 BX648917 EF142853 ABO93068 EF142854 ABO93069 L11695 AAA16073 XM_005252150 XP_005252207 XM_011518948 XP_011517250 XM_011518949 XP_011517251 XM_011518950 XP_011517252 NM_001130916 NP_001124388 NM_001306210 NP_001293139 NM_004612 NP_004603
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
Tissue Specificity	Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, Colorectal cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TGFβ RI CRISPR/Cas9 KO Plasmid (h) - sc-400153 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TGFβ RI HDR Plasmid (h) - sc-400153-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TGFβ RI Double Nickase Plasmid (h) - sc-400153-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TGFβ RI Double Nickase Plasmid (h2) - sc-400153-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TGFβ RI CRISPR Activation Plasmid (h) - sc-400153-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TGFβ RI CRISPR Activation Plasmid (h2) - sc-400153-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TGFβ RI Lentiviral Activation Particles (h) - sc-400153-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TGFβ RI Lentiviral Activation Particles (h2) - sc-400153-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TGFβ RI siRNA (h) - sc-40222 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TGFβ RI shRNA Plasmid (h) - sc-40222-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TGFβ RI shRNA (h) Lentiviral Particles - sc-40222-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TGF-beta RI/ALK-5 RNAi - H00007046-R04 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU051131 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2269 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2267 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2268 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2233 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2233 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

TGFBR1 siRNA (Human) - CRH4819 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TGFBR1 - MBS8234853 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TGFBR1 (NM_004612.2) - SHH426432 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TGFBR1(NM_004612.2) - SHL067814 from Creative biogene Category siRNA Species Reactivities Human

Human TGFBR1 siRNA - orb265321 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TGFBR1 shRNA Plasmid (Human) - CHH4819 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TGFBR1 miRNA 3'UTR clone - MiUTR1H-10352 from Creative biogene Species Reactivities Human

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