| Gene Symbol | CD44 |
|---|---|
| Entrez Gene | 960 |
| Alt Symbol | CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD44 molecule (Indian blood group) |
| Other Description | CD44 antigen|GP90 lymphocyte homing/adhesion receptor|Hermes antigen|cell surface glycoprotein CD44|chondroitin sulfate proteoglycan 8|epican|extracellular matrix receptor III|hematopoietic cell E- and L-selectin ligand|heparan sulfate proteoglycan|homing function and Indian blood group system|hyaluronate receptor|phagocytic glycoprotein 1 |
| Swissprots | Q9UJ36 Q16208 D3DR12 Q92493 Q13968 Q04858 Q13419 Q9UCB0 B6EAT9 Q9UC28 Q86T72 Q15861 A5YRN9 Q13957 Q13959 Q16064 Q9H5A5 Q13958 Q13961 P22511 Q16522 Q16065 Q86Z27 D3DR13 Q13967 Q96J24 Q9UC29 Q13960 Q8N694 Q16066 Q9UC30 P16070 Q13980 O95370 |
| Accessions | AAB13622 AAB13623 AAB13624 AAB13625 AAB13626 AAB13627 AAB13628 AAB30429 ABW75083 BAH30705 BAH57527 BAH57528 BAH57857 BAH57879 CBX54346 CDM22272 EAW68144 EAW68145 EAW68146 EAW68147 EAW68148 EAW68149 EAW68150 EAW68151 EAW68152 EAW68153 EAW68154 EAW68155 P16070 AB073901 AF086543 AF098641 AAC70782 AJ251595 CAB61878 AK123567 AK127622 AK129808 AK290424 BAF83113 AK297776 BAG60121 AK304467 BAG65282 AK307707 AL832642 CAD89965 AY101192 AAM50040 AY101193 AAM50041 BC004372 AAH04372 BC052287 AAH52287 BC067348 AAH67348 BF828674 BF872530 BG946113 CD721908 D28447 BAA05813 EF581837 ABQ59315 FJ216964 ACI46596 M24915 AAA35674 M25078 AAA36138 M59040 AAA51950 M83324 M83325 M83326 M83327 M83328 S66400 AAB27917 S82326 AAD14389 U40373 AAA82949 U94903 AAD00766 W47313 X55150 CAA38951 X55938 CAA39404 X56794 CAA40133 X62739 CAA44602 X66733 CAA47271 XM_005253231 XP_005253288 XM_005253232 XP_005253289 XM_005253233 XP_005253290 XM_005253234 XP_005253291 XM_005253235 XP_005253292 XM_005253238 XP_005253295 XM_005253239 XP_005253296 XM_005253240 XP_005253297 XM_006718388 XP_006718451 XM_006718390 XP_006718453 XM_011520482 XP_011518784 XM_011520483 XP_011518785 XM_011520484 XP_011518786 XM_011520485 XP_011518787 XM_011520486 XP_011518788 XM_011520487 XP_011518789 XM_011520488 XP_011518790 XM_011520489 XP_011518791 NM_000610 NP_000601 NM_001001389 NP_001001389 NM_001001390 NP_001001390 NM_001001391 NP_001001391 NM_001001392 NP_001001392 NM_001202555 NP_001189484 NM_001202556 NP_001189485 NM_001202557 NP_001189486 |
| Function | Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. {ECO:0000269|PubMed:16541107}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. {ECO:0000250}. |
| Tissue Specificity | Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. |
| Top Pathways | ECM-receptor interaction, Hematopoietic cell lineage, Epstein-Barr virus infection, MicroRNAs in cancer, Proteoglycans in cancer |