Gene Symbol | Pla2g2d |
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Entrez Gene | 18782 |
Alt Symbol | Splash, mGIID |
Species | Mouse |
Gene Type | protein-coding |
Description | phospholipase A2, group IID |
Other Description | GIID sPLA2|PLA2IID|group IID secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 2D|sPLA2-IID|secretory-type PLA, stroma-associated homolog |
Swissprots | Q9WVF6 Q9JLK0 Q3V4B8 |
Accessions | AAF09019 EDL13277 EDL13278 Q9WVF6 AF112983 AAD51391 AF124374 AAD42773 AF169407 AAF42987 AF169408 AAF42988 AK004232 BAE43166 AK018005 BAB31033 AK157392 BAE34077 AK158364 BAE34473 AK171797 BAE42668 AK172367 BAE42967 BC111806 AAI11807 XM_006538657 XP_006538720 NM_011109 NP_035239 |
Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. |
Subcellular Location | Isoform 1: Secreted {ECO:0000305}. |
Tissue Specificity | Expressed in several tissues including pancreas, spleen, thymus, skin, lung, and ovary. |
Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |
group IID sPLA 2 CRISPR/Cas9 KO Plasmid (m) - sc-422283 from Santa Cruz Biotechnology
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group IID sPLA 2 HDR Plasmid (m) - sc-422283-HDR from Santa Cruz Biotechnology
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group IID sPLA 2 Double Nickase Plasmid (m) - sc-422283-NIC from Santa Cruz Biotechnology
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group IID sPLA 2 Double Nickase Plasmid (m2) - sc-422283-NIC-2 from Santa Cruz Biotechnology
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group IID sPLA 2 CRISPR Activation Plasmid (m) - sc-422283-ACT from Santa Cruz Biotechnology
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group IID sPLA 2 CRISPR Activation Plasmid (m2) - sc-422283-ACT-2 from Santa Cruz Biotechnology
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group IID sPLA 2 Lentiviral Activation Particles (m) - sc-422283-LAC from Santa Cruz Biotechnology
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group IID sPLA 2 Lentiviral Activation Particles (m2) - sc-422283-LAC-2 from Santa Cruz Biotechnology
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group IID sPLA 2 siRNA (m) - sc-105417 from Santa Cruz Biotechnology
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group IID sPLA2 shRNA Plasmid (m) - sc-105417-SH from Santa Cruz Biotechnology
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group IID sPLA2 shRNA (m) Lentiviral Particles - sc-105417-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU086901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38820 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38820 from Sigma-Aldrich
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PLA2G2D siRNA (Mouse) - CRM3105 from Cohesion Biosciences
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shRNA set against Mouse PLA2G2D (NM_011109.2) - SHH376764 from Creative biogene
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shRNA set against Mouse Pla2g2d(NM_011109.2) - SHR118879 from Creative biogene
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Mouse PLA2G2D siRNA - orb282581 from Biorbyt
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PLA2G2D shRNA Plasmid (Mouse) - CHM3105 from Cohesion Biosciences
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PLA2G2D miRNA 3'UTR clone - MiUTR1M-09281 from Creative biogene
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