Gene Symbol | CHRNB2 |
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Entrez Gene | 1141 |
Alt Symbol | EFNL3, nAChRB2 |
Species | Human |
Gene Type | protein-coding |
Description | cholinergic receptor, nicotinic, beta 2 (neuronal) |
Other Description | acetylcholine receptor, nicotinic, beta 2 (neuronal)|beta2 human neuronal nicotinic acetylcholine receptor|cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)|neuronal acetylcholine receptor subunit beta-2|neuronal nicotinic acetylcholine receptor beta 2 |
Swissprots | Q9UEH9 P17787 |
Accessions | AAD45422 CAA05108 CAD88996 EAW53192 P17787 AK313470 BAG36255 BC075040 AAH75040 BC075041 AAH75041 R40506 U62437 AAB40115 X53179 CAA37320 Y08415 CAA69692 NM_000748 NP_000739 |
Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. {ECO:0000269|PubMed:22361591}. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
Top Pathways | Nicotine addiction, Neuroactive ligand-receptor interaction |
AChRβ2 CRISPR/Cas9 KO Plasmid (h) - sc-401641 from Santa Cruz Biotechnology
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AChRβ2 HDR Plasmid (h) - sc-401641-HDR from Santa Cruz Biotechnology
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AChRβ2 Double Nickase Plasmid (h) - sc-401641-NIC from Santa Cruz Biotechnology
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AChRβ2 Double Nickase Plasmid (h2) - sc-401641-NIC-2 from Santa Cruz Biotechnology
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AChRβ2 CRISPR Activation Plasmid (h) - sc-401641-ACT from Santa Cruz Biotechnology
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AChRβ2 CRISPR Activation Plasmid (h2) - sc-401641-ACT-2 from Santa Cruz Biotechnology
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AChRβ2 Lentiviral Activation Particles (h) - sc-401641-LAC from Santa Cruz Biotechnology
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AChRβ2 Lentiviral Activation Particles (h2) - sc-401641-LAC-2 from Santa Cruz Biotechnology
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AChRβ2 siRNA (h) - sc-42536 from Santa Cruz Biotechnology
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AChRβ2 shRNA Plasmid (h) - sc-42536-SH from Santa Cruz Biotechnology
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AChRβ2 shRNA (h) Lentiviral Particles - sc-42536-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU131811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1795 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1795 from Sigma-Aldrich
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CHRNB2 siRNA (Human) - CRH0818 from Cohesion Biosciences
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Nicotinic Acetylcholine Receptor beta 2 RNAi - H00001141-R01 from Novus Biologicals
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CHRNB2 - MBS8234543 from MyBioSource
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AChRβ2 CRISPR/Cas9 KO Plasmid (h2) - sc-401641-KO-2 from Santa Cruz Biotechnology
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AChRβ2 HDR Plasmid (h2) - sc-401641-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CHRNB2 (NM_000748.2) - SHH263633 from Creative biogene
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shRNA set against Human CHRNB2(NM_000748.2) - SHG177445 from Creative biogene
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Human CHRNB2 siRNA - orb261320 from Biorbyt
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CHRNB2 shRNA Plasmid (Human) - CHH0818 from Cohesion Biosciences
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CHRNB2 miRNA 3'UTR clone - MiUTR1H-02148 from Creative biogene
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