| Gene Symbol | PEAR1 |
|---|---|
| Entrez Gene | 375033 |
| Alt Symbol | JEDI, MEGF12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | platelet endothelial aggregation receptor 1 |
| Other Description | hPEAR1|multiple EGF-like domains protein 12|multiple EGF-like-domains 12|multiple epidermal growth factor-like domains protein 12 |
| Swissprots | Q8TEK2 Q5VY43 |
| Accessions | Q5VY43 AK074121 BAB84947 AK098809 BAC05419 BC172296 AAI72296 XM_005245141 XP_005245198 XM_006711302 XP_006711365 XM_011509508 XP_011507810 XM_011509509 XP_011507811 XM_011509510 XP_011507812 XM_011509511 XP_011507813 XM_011509512 XP_011507814 NM_001080471 NP_001073940 NM_207369 |
| Function | When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Detected on the cell surface in resting platelets. {ECO:0000269|PubMed:15851471}. |
| Tissue Specificity | Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages. |
Panoply™ Human PEAR1 Knockdown Stable Cell Line - CSC-DC011575 from Creative biogene
|