BAP1

Gene Symbol BAP1
Entrez Gene 8314
Alt Symbol HUCEP-13, UCHL2, hucep-6
Species Human
Gene Type protein-coding
Description BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Other Description cerebral protein 6|cerebral protein-13|ubiquitin carboxyl-terminal hydrolase BAP1
Swissprots Q6LEM0 Q7Z5E8 A8K993 Q92560
Accessions EAW65220 EAW65221 Q92560 AB002534 BAB46926 AF045581 AAC15970 AK092725 BAG52602 AK094499 AK225494 AK292608 BAF85297 AK295395 BAG58349 AK307274 AY130008 AAN05092 BC001596 AAH01596 BX647318 D87462 BAA13401 D88812 BAB46921 DA188433 DQ593715 DQ892545 ABM83471 DQ895756 ABM86682 XM_011534149 XP_011532451 XM_011534150 XP_011532452 XM_011534151 XP_011532453 XM_011534152 XP_011532454 NM_004656 NP_004647
Function Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytopl
Subcellular Location Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). {ECO:0000269|PubMed:24703950}.
Tissue Specificity Highly expressed in testis, placenta and ovary. Expressed in breast. {ECO:0000269|PubMed:9528852}.

Phospho-BAP1 (Ser592) Antibody - 9373 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or UV-treated (50 mJ, 1 hour recovery), using Phospho-BAP1 (Ser592) Antibody (upper) or β-Actin Antibody #4967 (lower) as a loading control.

BAP1 (D7W7O) Rabbit mAb - 13271 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7W7O
Western blot analysis of extracts from MOLT-4 and NCI-H226 cells using BAP1 (D7W7O) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

BAP1 (D1W9B) Rabbit mAb - 13187 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1W9B
Western blot analysis of extracts from MOLT-4 and NCI-H226 cells using BAP1 (D1W9B) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

BAP1 (C-18) - sc-8132 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BAP1 (C-18): sc-8132. Western blot analysis of BAP1 expression in A-431 (A) and HeLa (B) nuclear extracts.

BAP1 (F-6) - sc-48386 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BAP1 (F-6): sc-48386. Western blot analysis of BAP1 expression in SK-BR-3 (A), KNRK (B), A-431 (C) and HeLa (D) whole cell lysates.

BAP1 (3C11) - sc-13576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BAP1 (3C11): sc-13576. Western blot analysis of BAP1 expression in A-431 (A), HeLa (B) and SW480 (C) whole cell lysates.

BAP1 (H-300) - sc-28236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BAP1 (H-300): sc-28236. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

BAP1 (L-20) - sc-8133 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BAP1 (L-20): sc-8133. Western blot analysis of BAP1 expression in MCF7 (A) and SW480 (B) nuclear extracts.

BAP1 (C-4) - sc-28383 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
aBAP1 (C-4): sc-28383. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing nuclear staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Anti-BAP1 antibody - ab199396 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-BAP1 antibody (ab199396) at 1/375 dilution + HeLa cell lysate at 40 µg

Anti-BAP1 antibody - ab167250 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-BAP1 antibody (ab167250) at 1 µgLane 1 : BAP1 transfected 293T cell lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-BAP1 antibody [BP-1] - ab130202 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BP-1
All lanes : Anti-BAP1 antibody [BP-1] (ab130202) at 0.5 µg/mlLane 1 : Rat testicular tissue lysateLane 2 : Rat ovarian tissue lysate

Anti-BAP1 antibody - C-terminal - ab71642 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BAP1 antibody - C-terminal (ab71642) at 1/100 dilution + SK-BR-3 cell lysate at 12.5 µg

Anti-BAP1 antibody - N-terminal - ab187723 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BAP1 antibody - N-terminal (ab187723) at 1/1000 dilutionLane 1 : Mouse thymus whole cell extractLane 2 : HeLa whole cell extractLane 3 : Jurkat whole cell extract

Anti-BAP1 Antibody - LS-C74634 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-BAP1 Antibody (clone 1G8) - LS-C74637 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G8

Anti-BAP1 Antibody (aa337-440) - LS-C125161 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-BAP1 Antibody - LS-C126986 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-BAP1 Antibody (N-Terminus) - LS-C99602 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Anti-BAP1 Antibody (clone 1G8, Biotin) - LS-C141679 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G8

Anti-BAP1 Antibody (clone 1G8, DY650) - LS-C141680 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G8

Anti-BAP1 Antibody (clone 1G8, DY488) - LS-C141681 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G8

Anti-BAP1 Antibody (clone 1G8, HRP) - LS-C141682 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G8

Anti-BAP1 Antibody (clone 1G8, DY550) - LS-C141683 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G8

Anti-BAP1 Antibody (C-Terminus) - LS-C151563 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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