| Gene Symbol |
BAP1
|
| Entrez Gene |
8314
|
| Alt Symbol |
HUCEP-13, UCHL2, hucep-6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
|
| Other Description |
cerebral protein 6|cerebral protein-13|ubiquitin carboxyl-terminal hydrolase BAP1
|
| Swissprots |
Q6LEM0 Q7Z5E8 A8K993 Q92560
|
| Accessions |
EAW65220 EAW65221 Q92560 AB002534 BAB46926 AF045581 AAC15970 AK092725 BAG52602 AK094499 AK225494 AK292608 BAF85297 AK295395 BAG58349 AK307274 AY130008 AAN05092 BC001596 AAH01596 BX647318 D87462 BAA13401 D88812 BAB46921 DA188433 DQ593715 DQ892545 ABM83471 DQ895756 ABM86682 XM_011534149 XP_011532451 XM_011534150 XP_011532452 XM_011534151 XP_011532453 XM_011534152 XP_011532454 NM_004656 NP_004647
|
| Function |
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytopl
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). {ECO:0000269|PubMed:24703950}.
|
| Tissue Specificity |
Highly expressed in testis, placenta and ovary. Expressed in breast. {ECO:0000269|PubMed:9528852}.
|