BAP1

Gene Symbol	BAP1
Entrez Gene	8314
Alt Symbol	HUCEP-13, UCHL2, hucep-6
Species	Human
Gene Type	protein-coding
Description	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Other Description	cerebral protein 6|cerebral protein-13|ubiquitin carboxyl-terminal hydrolase BAP1
Swissprots	Q6LEM0 Q7Z5E8 A8K993 Q92560
Accessions	EAW65220 EAW65221 Q92560 AB002534 BAB46926 AF045581 AAC15970 AK092725 BAG52602 AK094499 AK225494 AK292608 BAF85297 AK295395 BAG58349 AK307274 AY130008 AAN05092 BC001596 AAH01596 BX647318 D87462 BAA13401 D88812 BAB46921 DA188433 DQ593715 DQ892545 ABM83471 DQ895756 ABM86682 XM_011534149 XP_011532451 XM_011534150 XP_011532452 XM_011534151 XP_011532453 XM_011534152 XP_011532454 NM_004656 NP_004647
Function	Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytopl
Subcellular Location	Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950). {ECO:0000269|PubMed:24703950}.
Tissue Specificity	Highly expressed in testis, placenta and ovary. Expressed in breast. {ECO:0000269|PubMed:9528852}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human BAP1 full length protein - ab188681 from Abcam Category Protein Prices $232.00 Sizes 50 µg Source E. coli Species Human

Human BAP1 full length protein - ab152849 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human BAP1 protein fragment - ab152850 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BAP1 Antibody Blocking Peptide - LS-E23287 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAP1 Antibody Blocking Peptide - LS-E6911 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAP1 Partial Recombinant Protein - H00008314-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human BAP1 Protein - H00008314-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BAP1 Peptide - P0984 from Novus Biologicals Category Peptide Species Human

BAP1 Peptide - P0983 from Novus Biologicals Category Peptide Species Human

BAP1-Antibody-C-term-Blocking-Peptide - BP2168b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BAP1-Antibody-N-term-Blocking-Peptide - BP2168a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-BAP1, CF - E-345-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

BAP1 - H00008314-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

BAP1 - H00008314-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BAP1 - H00008314-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BAP1 - H00008314-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BAP1 fusion protein - ag0597 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human BAP1 Protein, His-tagged - BAP1-554H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BAP1 protein, His-tagged - BAP1-167H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Ubiquitin carboxyl-terminal hydrolase BAP1(BAP1) - CSB-YP849763HU CSB-EP849763HU CSB-BP849763HU CSB-MP849763HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human His6-BAP1 Protein, CF - E-345 from R&D Systems Category Protein Prices $119.00 Sizes 50 µg Source E. coli -derived Contains an N-terminal 6-His tag Species Human

BAP1 - TP300378 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

BAP1 Protein - NBP1-83149PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

BAP1 Peptide, Human - M34GP01322H from Creative Peptides Category Peptide Source Synthetic. Species Human

BAP1 Recombinant Protein (Human) (OPED00010) - OPED00010 from Aviva Systems Biology Category Protein Prices $135.00 Sizes 50 µg Source E. Coli Species Human

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