PDE12

Gene Symbol	PDE12
Entrez Gene	201626
Alt Symbol	2'-PDE
Species	Human
Gene Type	protein-coding
Description	phosphodiesterase 12
Other Description	2',5'-phosphodiesterase 12|2'-phosphodiesterase|2-PDE|mitochondrial deadenylase
Swissprots	Q8TE78 Q6L8Q7 Q8NDU2 Q8IYU3 B4DTU8
Accessions	EAW65342 EAW65343 Q6L8Q7 AB115695 BAD20938 AK001526 AK074423 BAB85079 AK300374 BAG62110 AL831824 CAD38538 BC034978 BX647169 EU832450 ACE87622 EU832509 ACE87681 EU832590 ACE86992 HG495703 XM_011533475 XP_011531777 NM_177966 NP_808881
Function	Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:15231837}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse PDE12 ELISA Kit (Sandwich ELISA) - LS-F7090 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.051 ng/ml Range 0.156-10 ng/ml

Phosphodiesterase 12, ELISA Kit - MBS099847 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphodiesterase 12, ELISA Kit - MBS092464 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphodiesterase 12, ELISA Kit - MBS080952 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphodiesterase 12, ELISA Kit - MBS051071 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphodiesterase 12, ELISA Kit - MBS085378 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphodiesterase 12, ELISA Kit - MBS076968 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphodiesterase 12, ELISA Kit - MBS083151 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphodiesterase 12 (PDE12), ELISA Kit - MBS9313607 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Phosphodiesterase 12 (PDE12) - SEF658Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.051ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human PDE12 ELISA Kit - E029034 from Biobool Category ELISA Kit

anti-PDE12 antibody - ARG10790 from Arigo Biolaboratories Category ELISA Kit

anti-PDE12 antibody - ARG10789 from Arigo Biolaboratories Category ELISA Kit

Phosphodiesterase 12 (PDE12), ELISA Kit - MBS9370263 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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