APOBEC3G

Gene Symbol	APOBEC3G
Entrez Gene	60489
Alt Symbol	A3G, ARCD, ARP-9, ARP9, CEM-15, CEM15, MDS019, bK150C2.7, dJ494G10.1
Species	Human
Gene Type	protein-coding
Description	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
Other Description	APOBEC-related cytidine deaminase|APOBEC-related protein 9|DNA dC->dU editing enzyme|DNA dC->dU-editing enzyme APOBEC-3G|apolipoprotein B editing enzyme catalytic polypeptide-like 3G|apolipoprotein B mRNA editing enzyme cytidine deaminase|apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G|deoxycytidine deaminase|phorbolin-like protein MDS019
Swissprots	Q7Z2N1 Q5TF77 Q45F02 B2RDR9 Q7Z2N4 Q9H9H8 Q9HC16
Accessions	AAZ38722 ACB72734 EAW60292 Q9HC16 AB266487 BAF34652 AF182420 AAG14956 AK022802 AK092614 AK093635 AK310279 AK315650 BAG38016 BC009683 BC024268 AAH24268 BC061914 AAH61914 CR456472 CAG30358 CU013022 CAK54453 CU013310 CAK54752 DA457434 JF262036 AEA39616 JX915801 AGS14892 KC329531 AGI04219 XM_006724290 XP_006724353 NM_021822 NP_068594
Function	DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine in
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic. Small amount are found in the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 VIF.
Tissue Specificity	Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines; no expression detected in permissive lymphoid and non-lymphoid cell lines. Exists only in the LMM form in peripheral blood-derived resting CD4 T-cells and monocytes, both of which are refractory to HIV-1 infection. LMM is converted to a HMM complex when resting CD4 T-cells are activated or when monocytes are induced to differentiate into macrophages. This change correlates with increased susceptibility of these cells to HIV-1 infection. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:12167863, ECO:0000269|PubMed:20308164}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APOBEC3G full length protein - ab132965 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human APOBEC3G peptide - ab98980 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human APOBEC3G protein fragment - ab163725 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CEM15 / APOBEC3G Antibody Blocking Peptide - LS-E2337 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEM15 / APOBEC3G Blocking Peptide - LS-E2486 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEM15 / APOBEC3G Antibody Blocking Peptide - LS-E2487 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEM15 / APOBEC3G Antibody Blocking Peptide - LS-E2488 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEM15 / APOBEC3G Antibody Blocking Peptide - LS-E11854 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEM15 / APOBEC3G Antibody Blocking Peptide - LS-E26320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEM15 / APOBEC3G Antibody Blocking Peptide - LS-E30054 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

APOBEC3G Recombinant Protein - H00060489-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human APOBEC3G Protein - H00060489-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

APOBEC3G Peptide - P0353 from Novus Biologicals Category Peptide Species Human

APOBEC3G Peptide - P0352 from Novus Biologicals Category Peptide Species Human

CEM15-Antibody-Blocking-Peptide - BP1141b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APOBEC3G-Antibody-C-term-Blocking-peptide - BP13299b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APOBEC3G-CEM15-Antibody-C-term-Blocking-peptide - BP1351d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APOBEC3G-CEM15-Antibody-Center-E133-Blocking-peptide - BP1351b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CEM15-Antibody-N-term-Blocking-Peptide - BP1351a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APOBEC3G blocking peptide - GTX88548-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

APOBEC3G Peptide - GTX85084-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

ApoBEC3G Blocking Peptide - 33R-1295 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

APOBEC3G Peptide - AC21-1155-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

APOBEC3G - H00060489-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

APOBEC3G - H00060489-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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