SRGAP2

Gene Symbol	SRGAP2
Entrez Gene	23380
Alt Symbol	ARHGAP34, FNBP2, SRGAP2A, SRGAP3
Species	Human
Gene Type	protein-coding
Description	SLIT-ROBO Rho GTPase activating protein 2
Other Description	SLIT-ROBO GAP2|SLIT-ROBO Rho GTPase-activating protein 2|formin-binding protein 2|rho GTPase-activating protein 34
Swissprots	O75044
Accessions	CAH73674 CAH73675 CAH73676 EAW93550 O75044 AB007925 BAA32301 AK000885 BAG50836 AK057565 AK124556 AK293335 BAG56851 AK294060 BAG57406 AK295845 BAH12200 BC041635 BC063527 BC132872 AAI32873 BC132874 AAI32875 BC144343 AAI44344 BC150646 CA447513 DA110905 S68466 XM_005277510 XP_005277567 XM_005277511 XP_005277568 XM_005277514 XP_005277571 XM_005277515 XP_005277572 XM_011509354 XP_011507656 XM_011509355 XP_011507657 XM_011509356 XP_011507658 XM_011509357 XP_011507659 XM_011509358 XP_011507660 XM_011509359 XP_011507661 XM_011509360 XP_011507662 NM_001170637 NP_001164108 NM_001300952 NP_001287881 NM_015326 NP_056141 NM_001042758
Function	RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. {ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944}.
Subcellular Location	Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates from nucleus to cytoplasm during development. {ECO:0000250}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SRGAP2 Antibody Blocking Peptide - LS-E27247 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SRGAP3 Antibody Blocking Peptide - LS-E23711 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SRGAP3 Protein - H00009901-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SRGAP2 blocking peptide - GTX88045-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Goat anti SRGAP2 antibody Immunizing peptide - orb59785 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

SRGAP2 Peptide - AC21-2068-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SRGAP2 Peptide - 42-786P from ProSci Category Peptide Species Human

SRGAP2 fusion protein - ag18278 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SRGAP2 fusion protein - Ag19412 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SRGAP2, MYC/DDK-tagged - SRGAP2-88H from Creative Biomart Category Protein Source HEK293 Cells Species Human

Recombinant Human SLIT-ROBO Rho GTPase-activating protein 2(SRGAP2) ,partial - CSB-YP022662HU CSB-EP022662HU CSB-BP022662HU CSB-MP022662HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ARHGAP34 / SRGAP2 (transcript variant 1) - TP324139 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SRGAP2, Peptide - MBS427252 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

SRGAP3 Recombinant Protein Antigen - NBP1-88831PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SRGAP2 Recombinant Protein Antigen - NBP1-88830PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SRGAP2 Recombinant Protein Antigen - NBP1-89013PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SRGAP3 Recombinant Protein Antigen - NBP2-38521PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SRGAP2-Blocking-Peptide-C-term - BP21636b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRGAP2-Blocking-Peptide-C-term - BP21635b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRGAP2 Peptide, Human - M34GP15148H from Creative Peptides Category Peptide Source Synthetic. Species Human

SRGAP3 Peptide, Human - M34GP15149H from Creative Peptides Category Peptide Source Synthetic. Species Human

SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2), partial, Recombinant Protein - MBS1250342 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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