AKR1C3

Gene Symbol AKR1C3
Entrez Gene 8644
Alt Symbol DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member C3
Other Description 3-alpha hydroxysteroid dehydrogenase, type II|3-alpha-HSD type II, brain|aldo-keto reductase family 1 member C3|aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)|chlordecone reductase homolog HAKRb|dihydrodiol dehydrogenase 3|dihydrodiol dehydrogenase X|indanol dehydrogenase|prostaglandin F synthase|testosterone 17-beta-dehydrogenase 5|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type IIb 3-alpha hydroxysteroid dehydrogenase
Swissprots Q9UKL9 Q96DJ1 B4DL37 A8K2V0 Q5T2L1 P42330 Q9UCX1 Q99530 Q9UII3 Q96KI8
Accessions AAB41916 BAA88489 BAA92892 EAW86452 EAW86453 EAW86454 P42330 AB018580 BAA88488 AF149416 AAF07272 AK290365 BAF83054 AK296701 BAG59295 AK296829 BAG59399 AK310940 AK315411 AM392923 CAL37801 AV761799 BC001479 AAH01479 BC019230 AAH19230 BG547635 BT007286 AAP35950 D17793 BAA04619 DQ269985 ABB76132 DQ890679 ABM81605 DQ893860 ABM84786 GQ129450 ACT64584 GQ129451 ACT64585 H79159 S68288 AAD14011 NM_001253908 NP_001240837 NM_001253909 NP_001240838 NM_003739 NP_003730
Function Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate. {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.
Top Pathways Steroid hormone biosynthesis, Ovarian steroidogenesis, Arachidonic acid metabolism

DD1/2/3 (H-84) - sc-366531 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DD1/2/3 (H-84): sc-366531. Western blot analysis of DD1/2/3 expression in HeLa (A), Hep G2 (B) and A549 (C) whole cell lysates and human liver tissue extract (D).

DD3 (C-21) - sc-23795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DD3 (C-21): sc-23795. Western blot analysis of DD3 expression in Hep G2 whole cell lysate.

DD3 (D-9) - sc-398596 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DD3 (D-9): sc-398596. Western blot analysis of DD3 expression in HeLa (A), MOLT-4 (B), Jurkat (C), K-562 (D) and MDA-MB-231 (E) whole cell lysates.

Anti-AKR1C3 antibody - ab84327 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AKR1C3 antibody (ab84327) at 1/500 dilution + human fetal liver lysate

Anti-AKR1C3 antibody - ab196673 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKR1C3 antibody (ab196673) at 1/500 dilutionLane 1 : K562 cell extractLane 2 : Jurkat cell extractLane 3 : HepG2 cell extractLane 4 : A549 cell extractLane 5 : SW620 cell extract

Anti-AKR1C3 antibody - ab27491 from Abcam

Prices $382.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-AKR1C3 antibody (ab27491) at 0.03 µg/ml + Human breast lysate (35µg protein in RIPA buffer). developed using the ECL technique

Anti-AKR1C3 antibody - ab115326 from Abcam

Prices $378.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115326, at 5µg/ml, staining AKR1C3 in Formalin-fixed, Paraffin-embedded Human Small intestine tissue by Immunohistochemistry followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-AKR1C3 antibody - ab137546 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded NCI-N87 xenograft, labelling AKR1C3 with ab137546 at 1/100 dilution.

Anti-AKR1C3 antibody - ab170530 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKR1C3 antibody (ab170530) at 1/100 dilutionLane 1 : HeLa cell line lysateLane 2 : HepG2 cell line lysateLysates/proteins at 35 µg per lane.developed using the ECL technique

Anti-AKR1C3 antibody - ab89830 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-AKR1C3 antibody (ab89830) at 1 µg/ml + human liver tissue lysate at 50 µgdeveloped using the ECL technique

Anti-AKR1C3 antibody [NP6.G6.A6] - ab49680 from Abcam

Prices $373.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone NP6.G6.A6

Anti-AKR1C3 antibody - C-terminal - ab137545 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-AKR1C3 antibody - C-terminal (ab137545) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-DDX / AKR1C3 Antibody - LS-C136834 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DDX / AKR1C3 Antibody (aa97-146) - LS-C145932 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AKR1C3 antibody LS-C145932 Western blot of COL0205 Cell lysate. Antibody concentration 1 ug/ml.

Anti-DDX / AKR1C3 Antibody (aa107-135, APC) - LS-C251112 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DDX / AKR1C3 Antibody (aa107-135, Biotin) - LS-C251111 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DDX / AKR1C3 Antibody (aa107-135, FITC) - LS-C251113 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DDX / AKR1C3 Antibody (aa10-36) - LS-C156217 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
AKR1C3 Antibody western blot of K562 cell line lysates (35 ug/lane). The AKR1C3 antibody detected the AKR1C3 protein (arrow).

Anti-DDX / AKR1C3 Antibody (aa107-135, Azide-free, HRP) - LS-C251114 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DDX / AKR1C3 Antibody - LS-C192943 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of Jurkat cell line, using AKR1C3 antibody.

Anti-DDX / AKR1C3 Antibody (aa191-240) - LS-C198607 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa/COLO cells, using AKR1C3 Antibody. The lane on the right was incubated with synthetic peptide.

Anti-DDX / AKR1C3 Antibody (aa107-135, PE) - LS-C251115 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DDX / AKR1C3 Antibody (aa10-36, AP) - LS-C251116 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DDX / AKR1C3 Antibody (aa10-36, APC) - LS-C251117 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DDX / AKR1C3 Antibody (aa10-36, Biotin) - LS-C251118 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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