AKR1C3

Gene Symbol AKR1C3
Entrez Gene 8644
Alt Symbol DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member C3
Other Description 3-alpha hydroxysteroid dehydrogenase, type II|3-alpha-HSD type II, brain|aldo-keto reductase family 1 member C3|aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)|chlordecone reductase homolog HAKRb|dihydrodiol dehydrogenase 3|dihydrodiol dehydrogenase X|indanol dehydrogenase|prostaglandin F synthase|testosterone 17-beta-dehydrogenase 5|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type IIb 3-alpha hydroxysteroid dehydrogenase
Swissprots Q9UKL9 Q96DJ1 B4DL37 A8K2V0 Q5T2L1 P42330 Q9UCX1 Q99530 Q9UII3 Q96KI8
Accessions AAB41916 BAA88489 BAA92892 EAW86452 EAW86453 EAW86454 P42330 AB018580 BAA88488 AF149416 AAF07272 AK290365 BAF83054 AK296701 BAG59295 AK296829 BAG59399 AK310940 AK315411 AM392923 CAL37801 AV761799 BC001479 AAH01479 BC019230 AAH19230 BG547635 BT007286 AAP35950 D17793 BAA04619 DQ269985 ABB76132 DQ890679 ABM81605 DQ893860 ABM84786 GQ129450 ACT64584 GQ129451 ACT64585 H79159 S68288 AAD14011 NM_001253908 NP_001240837 NM_001253909 NP_001240838 NM_003739 NP_003730
Function Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate. {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.
Top Pathways Steroid hormone biosynthesis, Ovarian steroidogenesis, Arachidonic acid metabolism

Aldo-keto reductase family 1 member C3 (AKR1C3), Human, ELISA Kit - CSB-EL001544HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Aldo-keto reductase family 1 member C3 (AKR1C3), Human, ELISA Kit - E01A1373 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t
Sensitivity 1.0pg/ml
Range 250-5000pg/ml

Aldo-keto reductase family 1 member C3, AKR1C3, Human, ELISA Kit - E0603h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Aldo-Keto Reductase Family 1 Member C3, AKR1C3/DD3, Human, ELISA Kit - YHB0134Hu from ARP American Research Products

Category ELISA Kit

prostaglandin F synthase (PGFS) , ELISA Kit - MBS9310151 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7220102 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7238656 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7224577 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7250513 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7241566 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7225204 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7217036 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7226814 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7200973 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7205329 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7230674 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aldo-keto reductase family 1 member C3 (AKR1C3), ELISA Kit - MBS7240695 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) , ELISA Kit - MBS937892 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human AKR1C3 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 25 pg/ml -1600 pg/ml.

Human Aldo-keto reductase family 1 member C3(AKR1C3) ELISA kit - CSB-EL001544HU from Cusabio

Category ELISA Kit
Sensitivity 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml

Human DDX / AKR1C3 ELISA Kit (Sandwich ELISA) - LS-F14889 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.156-10 ng/ml

Human Aldo-keto reductase family 1 member C3 (AKR1C3) ELISA Kit - EKC32522 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml

Custom Human AKR1C3 ELISA - ELH-AKR1C3-1 from RayBiotech

Category ELISA Kit
Prices $627.00, $1,128.60, $2,508.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human AKR1C3 ELISA Kit - orb384464 from Biorbyt

Category ELISA Kit
Prices $1,411.00, $2,448.00, $5,321.00
Sizes 96 assays, 192 assays, 480 assays

Human Aldo-keto reductase family 1 member C3 ELISA Kit - EKE55608 from Biomatik

Category ELISA Kit
Prices $685.00, $2,913.00, $5,483.00
Sizes 96 t, 5x96t, 10x96t
Range 0.156-10 ng/mL

Human AKR1C3 ELISA Kit - E001322 from Biobool

Category ELISA Kit
Sensitivity 1.0 pg/mL.
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