AKR1C3

Gene Symbol	AKR1C3
Entrez Gene	8644
Alt Symbol	DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
Species	Human
Gene Type	protein-coding
Description	aldo-keto reductase family 1, member C3
Other Description	3-alpha hydroxysteroid dehydrogenase, type II|3-alpha-HSD type II, brain|aldo-keto reductase family 1 member C3|aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)|chlordecone reductase homolog HAKRb|dihydrodiol dehydrogenase 3|dihydrodiol dehydrogenase X|indanol dehydrogenase|prostaglandin F synthase|testosterone 17-beta-dehydrogenase 5|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type IIb 3-alpha hydroxysteroid dehydrogenase
Swissprots	Q9UKL9 Q96DJ1 B4DL37 A8K2V0 Q5T2L1 P42330 Q9UCX1 Q99530 Q9UII3 Q96KI8
Accessions	AAB41916 BAA88489 BAA92892 EAW86452 EAW86453 EAW86454 P42330 AB018580 BAA88488 AF149416 AAF07272 AK290365 BAF83054 AK296701 BAG59295 AK296829 BAG59399 AK310940 AK315411 AM392923 CAL37801 AV761799 BC001479 AAH01479 BC019230 AAH19230 BG547635 BT007286 AAP35950 D17793 BAA04619 DQ269985 ABB76132 DQ890679 ABM81605 DQ893860 ABM84786 GQ129450 ACT64584 GQ129451 ACT64585 H79159 S68288 AAD14011 NM_001253908 NP_001240837 NM_001253909 NP_001240838 NM_003739 NP_003730
Function	Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate. {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.
Top Pathways	Steroid hormone biosynthesis, Ovarian steroidogenesis, Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AKR1C3 / DDH3 Lysate(Denatured) - H00008644-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

AKR1C3 / DDH3 Lysate(Denatured) - H00008644-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

AKR1C3 overexpression lysate - LY418464 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

Aldo-keto Reductase 1C3/AKR1C3 Overexpression Lysate (Denatured) - H00008644-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Aldo-keto Reductase 1C3/AKR1C3 Overexpression Lysate (Denatured) - H00008644-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

DD3 (h4): 293T Lysate - sc-158432 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

DD3 (h5): 293 Lysate - sc-158433 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Aldo-keto Reductase 1C3/AKR1C3 Overexpression Lysate (Native) - NBP2-07959 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Aldo-keto Reductase 1C3/AKR1C3 Overexpression Lysate (Denatured) - H00008644-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human AKR1C3 Knockdown Stable Cell Line - CSC-DC000458 from Creative biogene Category Cell Line Species Human

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