| Gene Symbol | AKR1C3 |
|---|---|
| Entrez Gene | 8644 |
| Alt Symbol | DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS |
| Species | Human |
| Gene Type | protein-coding |
| Description | aldo-keto reductase family 1, member C3 |
| Other Description | 3-alpha hydroxysteroid dehydrogenase, type II|3-alpha-HSD type II, brain|aldo-keto reductase family 1 member C3|aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)|chlordecone reductase homolog HAKRb|dihydrodiol dehydrogenase 3|dihydrodiol dehydrogenase X|indanol dehydrogenase|prostaglandin F synthase|testosterone 17-beta-dehydrogenase 5|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type IIb 3-alpha hydroxysteroid dehydrogenase |
| Swissprots | Q9UKL9 Q96DJ1 B4DL37 A8K2V0 Q5T2L1 P42330 Q9UCX1 Q99530 Q9UII3 Q96KI8 |
| Accessions | AAB41916 BAA88489 BAA92892 EAW86452 EAW86453 EAW86454 P42330 AB018580 BAA88488 AF149416 AAF07272 AK290365 BAF83054 AK296701 BAG59295 AK296829 BAG59399 AK310940 AK315411 AM392923 CAL37801 AV761799 BC001479 AAH01479 BC019230 AAH19230 BG547635 BT007286 AAP35950 D17793 BAA04619 DQ269985 ABB76132 DQ890679 ABM81605 DQ893860 ABM84786 GQ129450 ACT64584 GQ129451 ACT64585 H79159 S68288 AAD14011 NM_001253908 NP_001240837 NM_001253909 NP_001240838 NM_003739 NP_003730 |
| Function | Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate. {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}. |
| Top Pathways | Steroid hormone biosynthesis, Ovarian steroidogenesis, Arachidonic acid metabolism |