AKR1C3

Gene Symbol	AKR1C3
Entrez Gene	8644
Alt Symbol	DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
Species	Human
Gene Type	protein-coding
Description	aldo-keto reductase family 1, member C3
Other Description	3-alpha hydroxysteroid dehydrogenase, type II|3-alpha-HSD type II, brain|aldo-keto reductase family 1 member C3|aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)|chlordecone reductase homolog HAKRb|dihydrodiol dehydrogenase 3|dihydrodiol dehydrogenase X|indanol dehydrogenase|prostaglandin F synthase|testosterone 17-beta-dehydrogenase 5|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type IIb 3-alpha hydroxysteroid dehydrogenase
Swissprots	Q9UKL9 Q96DJ1 B4DL37 A8K2V0 Q5T2L1 P42330 Q9UCX1 Q99530 Q9UII3 Q96KI8
Accessions	AAB41916 BAA88489 BAA92892 EAW86452 EAW86453 EAW86454 P42330 AB018580 BAA88488 AF149416 AAF07272 AK290365 BAF83054 AK296701 BAG59295 AK296829 BAG59399 AK310940 AK315411 AM392923 CAL37801 AV761799 BC001479 AAH01479 BC019230 AAH19230 BG547635 BT007286 AAP35950 D17793 BAA04619 DQ269985 ABB76132 DQ890679 ABM81605 DQ893860 ABM84786 GQ129450 ACT64584 GQ129451 ACT64585 H79159 S68288 AAD14011 NM_001253908 NP_001240837 NM_001253909 NP_001240838 NM_003739 NP_003730
Function	Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate. {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.
Top Pathways	Steroid hormone biosynthesis, Ovarian steroidogenesis, Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human AKR1C3 full length protein - ab167984 from Abcam Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

AKR1C3 peptide (311-323) - ab45679 from Abcam Category Peptide Prices $176.00 Sizes 100 µg Species Human

Human AKR1C3 full length protein - ab87417 from Abcam Category Protein Prices $235.00, $866.00 Sizes 100 µg, 500 µg Source E. coli Species Human

DDX / AKR1C3 Antibody Blocking Peptide - LS-E79 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX / AKR1C3 Antibody Blocking Peptide - LS-E1131 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX / AKR1C3 Antibody Blocking Peptide - LS-E25822 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX / AKR1C3 Antibody Blocking Peptide - LS-E22461 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein - NBC1-21051 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

Aldo-keto Reductase 1C3/AKR1C3 Recombinant Protein - H00008644-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Aldo-keto Reductase 1C3/AKR1C3 Recombinant Protein - P3481 from Novus Biologicals Category Protein Prices $549.00 Sizes 100 µg Species Human

AKR1C3-Antibody-N-term-Blocking-peptide - BP10158a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AKR1C3-Antibody-Center-Blocking-peptide - BP11656c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AKR1C3 blocking peptide - GTX89620-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Aldo-keto Reductase 1C3/AKR1C3, CF - 7678-DH-020 from R&D Systems Category Protein Source E. coli-derived, Asp2-Tyr323, with an N-terminal Met and 6-His tag

AKR1C3 Protein (OPPA01849) - OPPA01849 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human AKR1C3 protein - orb90023 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli Species Human

AKR1C3 protein (His tag) - 80R-1116 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

AKR1C3 Peptide - AC21-0654-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AKR1C3 / DDH3 (1-323, His-tag) - AR09154PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

AKR1C3 / DDH3 (1-323, His-tag) - AR09154PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

AKR1C3 / DDH3 - H00008644-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AKR1C3 / DDH3 - H00008644-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AKR1C3 / DDH3 - P3481 from Acris Antibodies Category Protein Prices $500.00 Sizes 100 µg Species Human

Aldo-Keto Reductase Family 1 Member C3, Human Recombinant - 228-10041-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human AKR1C3 - 228-10041-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

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