| Gene Symbol |
INPP5K
|
| Entrez Gene |
51763
|
| Alt Symbol |
PPS, SKIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inositol polyphosphate-5-phosphatase K
|
| Other Description |
inositol polyphosphate 5-phosphatase K|skeletal muscle and kidney-enriched inositol phosphatase
|
| Swissprots |
Q9P2R5 Q9NPJ5 B2R750 Q15733 D3DTH8 Q9BT40 B2R6I2
|
| Accessions |
BAA92342 EAW90614 EAW90615 EAW90616 EAW90617 EAW90618 Q9BT40 AB036829 BAA92340 AB036830 BAA92341 AK297955 BAH12695 AK303907 BAH14079 AK307293 AK312585 BAG35479 AK312844 BAG35697 BC004362 AAH04362 BG722885 BM510617 DQ892815 ABM83741 DQ896061 ABM87060 U45973 AAB03214 XM_005256683 XP_005256740 XM_005256685 XP_005256742 XM_005256686 XP_005256743 XM_011523934 XP_011522236 XM_011523935 XP_011522237 XM_011523936 XP_011522238 NM_001135642 NP_001129114 NM_016532 NP_057616 NM_130766 NP_570122
|
| Function |
Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton. {ECO:0000269|PubMed:10753883}.
|
| Subcellular Location |
Endoplasmic reticulum {ECO:0000269|PubMed:12536145}. Note=Following stimulation with EGF, translocates to membrane ruffles.
|
| Tissue Specificity |
Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney. {ECO:0000269|PubMed:10753883}.
|
| Top Pathways |
Insulin signaling pathway, Inositol phosphate metabolism, Phosphatidylinositol signaling system
|