NBN

Gene Symbol	NBN
Entrez Gene	4683
Alt Symbol	AT-V1, AT-V2, ATV, NBS, NBS1, P95
Species	Human
Gene Type	protein-coding
Description	nibrin
Other Description	Nijmegen breakage syndrome 1 (nibrin)|cell cycle regulatory protein p95|p95 protein of the MRE11/RAD50 complex
Swissprots	Q53FM6 B2RNC5 B2R626 Q7LDM2 Q32NF7 O60934 Q63HR6 O60672
Accessions	AAC62232 AAS59158 AEX07903 AGW81285 AGW81286 AGW81287 AGW81288 AGW81289 AGW81290 AGW81291 BAA28616 CAI45369 EAW91660 EAW91661 O60934 AF051334 AAC39732 AF058696 AAC39752 AK001017 AK223256 BAD96976 AK289848 BAF82537 AK312410 BAG35323 BC005293 BC016762 AAH16762 BC040519 BC071590 BC108650 AAI08651 BC136802 AAI36803 BC136803 AAI36804 BC143065 AAI43066 BC143066 AAI43067 BC144413 BC146797 AAI46798 BX640816 CAH56160 DA634817 XM_005250923 XP_005250980 XM_011517044 XP_011515346 XM_011517045 XP_011515347 XM_011517046 XP_011515348 XR_928335 NM_001024688 NP_001019859 NM_002485 NP_002476
Function	Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of
Subcellular Location	Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000269|PubMed:12470659, ECO:0000269|PubMed:15916964}. Chromosome, telomere {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
Tissue Specificity	Ubiquitous. Expressed at high levels in testis.
Top Pathways	Homologous recombination

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Phospho-NBN / Nibrin (Ser278) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1436 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Human/Rat Phospho-NBN / Nibrin (Ser343) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1571 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Human NBN / Nibrin ELISA Kit (Cell-Based ELISA) - LS-F2219 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Rabbit anti-NBS1 Antibody, Affinity Purified - PLA0179 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Artemin (ARTN), Human, ELISA Kit - SEJ596Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.056ng/mL Range 0.156-10ng/mL

p95-NBS1 Colorimetric Cell-Based ELISA Kit - CB5527 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

p95-NBS1 (Phospho-Ser278) Colorimetric Cell-Based ELISA Kit - CBP1474 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

p95-NBS1 (Phospho-Ser343) Colorimetric Cell-Based ELISA Kit - CBP1622 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Nibrin (NBN), ELISA Kit - MBS9313261 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin (NBN), ELISA Kit - MBS9304561 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin, NBN, ELISA Kit - MBS2602736 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.06 ng/ml. Range 20 ng/ml-0.312 ng/ml

ELISA Kit for Artemin (ARTN) - SEJ596Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human NBS1 (Phospho-S343) ELISA Kit - orb384982 from Biorbyt Category ELISA Kit Prices $1,122.00, $1,938.00, $4,182.00 Sizes 96 assays, 192 assays, 480 assays

Human NBN ELISA Kit - E026507 from Biobool Category ELISA Kit Sensitivity 0.06 ng/ml.

anti-p95/NBS1 phospho (Ser343) antibody - ARG51561 from Arigo Biolaboratories Category ELISA Kit

Nibrin (NBN), ELISA Kit - MBS2610267 from MyBioSource Category ELISA Kit Prices $300.00, $475.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin, ELISA Kit - MBS2605990 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin, ELISA Kit - MBS2605872 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin, ELISA Kit - MBS283976 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin , ELISA Kit - MBS2604850 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin, ELISA Kit - MBS2606332 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin, ELISA Kit - MBS2607752 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin, ELISA Kit - MBS2603425 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin, ELISA Kit - MBS2608316 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nibrin, ELISA Kit - MBS2604209 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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