Gene Symbol | BEST2 |
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Entrez Gene | 54831 |
Alt Symbol | VMD2L1 |
Species | Human |
Gene Type | protein-coding |
Description | bestrophin 2 |
Other Description | VMD2-like gene 1|bestrophin-2|vitelliform macular dystrophy 2-like 1|vitelliform macular dystrophy 2-like protein 1 |
Swissprots | Q8NFU1 Q53YQ8 Q9NXP0 |
Accessions | EAW84304 Q8NFU1 AF440756 AAM76995 AK000139 BAA90970 AK225232 AY515705 AAR99655 BC169236 BC169237 BC169238 XM_005259963 XP_005260020 NM_017682 NP_060152 |
Function | Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO:0000269|PubMed:11904445, ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Mainly confined to the retinal pigment epithelium and colon. {ECO:0000269|PubMed:12032738}. |
Top Pathways | Salivary secretion |
Bestrophin-2 CRISPR/Cas9 KO Plasmid (h) - sc-412345 from Santa Cruz Biotechnology
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Bestrophin-2 HDR Plasmid (h) - sc-412345-HDR from Santa Cruz Biotechnology
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Bestrophin-2 Double Nickase Plasmid (h) - sc-412345-NIC from Santa Cruz Biotechnology
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Bestrophin-2 Double Nickase Plasmid (h2) - sc-412345-NIC-2 from Santa Cruz Biotechnology
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Bestrophin-2 CRISPR Activation Plasmid (h) - sc-412345-ACT from Santa Cruz Biotechnology
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Bestrophin-2 CRISPR Activation Plasmid (h2) - sc-412345-ACT-2 from Santa Cruz Biotechnology
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Bestrophin-2 Lentiviral Activation Particles (h) - sc-412345-LAC from Santa Cruz Biotechnology
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Bestrophin-2 Lentiviral Activation Particles (h2) - sc-412345-LAC-2 from Santa Cruz Biotechnology
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Bestrophin-2 siRNA (h) - sc-72639 from Santa Cruz Biotechnology
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Bestrophin-2 shRNA Plasmid (h) - sc-72639-SH from Santa Cruz Biotechnology
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Bestrophin-2 shRNA (h) Lentiviral Particles - sc-72639-V from Santa Cruz Biotechnology
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Bestrophin 2 RNAi - H00054831-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN3949 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3949 from Sigma-Aldrich
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BEST2 siRNA (Human) - CRJ0250 from Cohesion Biosciences
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BEST2 - MBS8223185 from MyBioSource
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shRNA set against Human Best2 (NM_017682.2) - SHH246378 from Creative biogene
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Human BEST2 siRNA - orb270751 from Biorbyt
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BEST2 shRNA Plasmid (Human) - CHJ0250 from Cohesion Biosciences
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BEST2 miRNA 3'UTR clone - MiUTR1H-00875 from Creative biogene
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