Gene Symbol | TAS2R38 |
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Entrez Gene | 5726 |
Alt Symbol | PTC, T2R38, T2R61 |
Species | Human |
Gene Type | protein-coding |
Description | taste receptor, type 2, member 38 |
Other Description | PTC bitter taste receptor|taste receptor type 2 member 38|taste receptor type 2 member 61 |
Swissprots | A4D1U6 Q645W3 P59533 Q86UK3 Q2M3E8 P59552 |
Accessions | AAM19322 AAM63545 AAP14666 AAP14667 AFH77562 BAD98025 BAD98026 BAD98027 CAI53572 CAI53575 EAL24011 EAW83993 P59533 BC104933 AAI04934 BC104937 AAI04938 NM_176817 NP_789787 |
Function | Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. |
Top Pathways | Taste transduction |
T2R38 CRISPR/Cas9 KO Plasmid (h) - sc-402279 from Santa Cruz Biotechnology
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T2R38 HDR Plasmid (h) - sc-402279-HDR from Santa Cruz Biotechnology
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T2R38 Double Nickase Plasmid (h) - sc-402279-NIC from Santa Cruz Biotechnology
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T2R38 Double Nickase Plasmid (h2) - sc-402279-NIC-2 from Santa Cruz Biotechnology
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T2R38 CRISPR Activation Plasmid (h) - sc-402279-ACT from Santa Cruz Biotechnology
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T2R38 CRISPR Activation Plasmid (h2) - sc-402279-ACT-2 from Santa Cruz Biotechnology
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T2R38 Lentiviral Activation Particles (h) - sc-402279-LAC from Santa Cruz Biotechnology
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T2R38 Lentiviral Activation Particles (h2) - sc-402279-LAC-2 from Santa Cruz Biotechnology
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T2R38 siRNA (h) - sc-45339 from Santa Cruz Biotechnology
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T2R38 shRNA Plasmid (h) - sc-45339-SH from Santa Cruz Biotechnology
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T2R38 shRNA (h) Lentiviral Particles - sc-45339-V from Santa Cruz Biotechnology
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TAS2R38 RNAi - H00005726-R02 from Novus Biologicals
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MISSION® esiRNA - EHU155201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21022 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21022 from Sigma-Aldrich
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TAS2R38 siRNA (Human) - CRH3870 from Cohesion Biosciences
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TAS2R38 - MBS8228949 from MyBioSource
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T2R38 CRISPR/Cas9 KO Plasmid (h2) - sc-402279-KO-2 from Santa Cruz Biotechnology
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T2R38 HDR Plasmid (h2) - sc-402279-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TAS2R38 (NM_176817.4) - SHH423528 from Creative biogene
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Human TAS2R38 siRNA - orb264372 from Biorbyt
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TAS2R38 shRNA Plasmid (Human) - CHH3870 from Cohesion Biosciences
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TAS2R38 miRNA 3'UTR clone - MiUTR4H-TG08775 from Creative biogene
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