Gene Symbol | CACNG4 |
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Entrez Gene | 27092 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | calcium channel, voltage-dependent, gamma subunit 4 |
Other Description | TARP gamma-4|neuronal voltage-gated calcium channel gamma-4 subunit|transmembrane AMPAR regulatory protein gamma-4|voltage-dependent calcium channel gamma-4 subunit |
Swissprots | Q9UBN1 B2RCK0 |
Accessions | AAF03090 EAW89020 EAW89021 Q9UBN1 AF162692 AAF14538 AK055232 AK315149 BAG37597 AL526464 AL713655 CAD28464 AL831834 BC004504 BC032765 BC034532 AAH34532 BF508806 DQ891815 ABM82741 DQ895000 ABM85926 NM_014405 NP_055220 |
Function | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:21172611}. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
L-type Ca ++ CP γ4 CRISPR/Cas9 KO Plasmid (h) - sc-411956 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 HDR Plasmid (h) - sc-411956-HDR from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 Double Nickase Plasmid (h) - sc-411956-NIC from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 Double Nickase Plasmid (h2) - sc-411956-NIC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 CRISPR Activation Plasmid (h) - sc-411956-ACT from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 CRISPR Activation Plasmid (h2) - sc-411956-ACT-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 Lentiviral Activation Particles (h) - sc-411956-LAC from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 Lentiviral Activation Particles (h2) - sc-411956-LAC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 siRNA (h) - sc-94093 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 shRNA Plasmid (h) - sc-94093-SH from Santa Cruz Biotechnology
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L-type Ca ++ CP γ4 shRNA (h) Lentiviral Particles - sc-94093-V from Santa Cruz Biotechnology
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CACNG4 RNAi - H00027092-R01 from Novus Biologicals
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MISSION® esiRNA - EHU031891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5276 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5276 from Sigma-Aldrich
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CACNG4 siRNA (Human) - CRH8959 from Cohesion Biosciences
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CACNG4 - MBS8210102 from MyBioSource
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shRNA set against Human CACNG4 (NM_014405.3) - SHH253501 from Creative biogene
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CACNG4 shRNA Plasmid (Human) - CHH8959 from Cohesion Biosciences
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CACNG4 miRNA 3'UTR clone - MiUTR4H-TG01566 from Creative biogene
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