| Gene Symbol | Mgat5b |
|---|---|
| Entrez Gene | 268510 |
| Alt Symbol | C330018B01, GnT-IX, mGnTVB |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | mannoside acetylglucosaminyltransferase 5, isoenzyme B |
| Other Description | GNT-Vb|N-acetylglucosaminyl-transferase Vb|N-acetylglucosaminyltranferase VB|N-acetylglucosaminyltransferase IX|UDP-N-acetylglucosamine: alpha1,6-D-mannoside beta1,6-N-acetylglucosaminyltransferase b|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B|alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B|beta1,6-N-acetylglucosaminyltransferase IX (GnT-IX)|glcNAc-T Vb|mannoside acetylglucosaminyltransferase 5B |
| Swissprots | Q765H6 Q8C7T8 |
| Accessions | EDL34607 EDL34608 Q765H6 AB116028 BAD08454 AB119127 BAC87707 AK049266 BAC33645 BC063084 BC094604 AAH94604 XM_006533417 XP_006533480 XM_011249047 XP_011247349 XR_388471 NM_172948 NP_766536 |
| Function | Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:16413118}; Single-pass type II membrane protein {ECO:0000269|PubMed:16413118}. |
| Tissue Specificity | Present in brain (at protein level). Predominantly expressed in cerebrum and cerebellum. {ECO:0000269|PubMed:16413118}. |
| Top Pathways | N-Glycan biosynthesis, Other types of O-glycan biosynthesis |