ITK
| Gene Symbol | ITK |
|---|---|
| Entrez Gene | 3702 |
| Alt Symbol | EMT, LPFS1, LYK, PSCTK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | IL2-inducible T-cell kinase |
| Other Description | IL-2-inducible T cell kinase|IL-2-inducible T-cell kinase|T-cell-specific kinase|homolog of mouse T-cell itk/tsk|interleukin-2-inducible T cell kinase|interleukin-2-inducible T-cell kinase|kinase EMT|tyrosine-protein kinase ITK/TSK|tyrosine-protein kinase LYK |
| Swissprots | B2R752 Q32ML7 Q08881 |
| Accessions | EAW61608 Q08881 AB209622 BAD92859 AK303609 BAG64622 AK311654 AK312846 BAG35699 BC094701 BC109077 AAI09078 BC109078 AAI09079 BX538196 CAD98063 D13720 BAA02873 NM_005546 NP_005537 |
| Function | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ulti |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17060314}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. |
| Tissue Specificity | T-cell lines and natural killer cell lines. |
| Top Pathways | T cell receptor signaling pathway, Leukocyte transendothelial migration, Chemokine signaling pathway |
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