| Gene Symbol | RPN2 |
|---|---|
| Entrez Gene | 6185 |
| Alt Symbol | RIBIIR, RPN-II, RPNII, SWP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribophorin II |
| Other Description | dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit|dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2|oligosaccharyltransferase complex subunit (non-catalytic)|ribophorin-2 |
| Swissprots | Q96E21 Q5JYR6 Q9UBE1 Q6IBA5 P04844 Q9BUQ3 |
| Accessions | CAB54801 EAW76073 EAW76074 EAW76075 EAW76076 EAW76077 P04844 AK096243 BAG53237 AK296126 BAG58872 AK308683 AK315801 BAG38143 BC002380 AAH02380 BC003560 AAH03560 BC013028 AAH13028 BC020222 AAH20222 BF923732 BG718075 CR456899 CAG33180 DB449190 DQ892347 ABM83273 DQ895552 ABM86478 Y00282 CAA68393 XM_005260491 XP_005260548 XM_006723849 XP_006723912 XM_006723850 XP_006723913 XM_006723851 XP_006723914 XM_006723852 XP_006723915 NM_001135771 NP_001129243 NM_002951 NP_002942 |
| Function | Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in all tissues tested. |
| Top Pathways | N-Glycan biosynthesis, Protein processing in endoplasmic reticulum |