TRIM25

Gene Symbol	TRIM25
Entrez Gene	7706
Alt Symbol	EFP, RNF147, Z147, ZNF147
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 25
Other Description	E3 ubiquitin/ISG15 ligase TRIM25|RING finger protein 147|estrogen-responsive finger protein|tripartite motif protein TRIM25|tripartite motif-containing 25|tripartite motif-containing protein 25|ubiquitin/ISG15-conjugating enzyme TRIM25|zinc finger protein 147 (estrogen-responsive finger protein)|zinc finger protein-147
Swissprots	Q14258
Accessions	EAW94523 EAW94524 EAW94525 Q14258 AB208994 BAD92231 AK024597 AK310720 BC013752 BC016924 AAH16924 BC038247 BC042541 AAH42541 BC053605 BC106889 BC106890 BC114339 BM146967 BX538220 CF121587 D21205 BAA04747 NM_005082 NP_005073
Function	Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. {ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17392790}. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:15130519}.
Top Pathways	RIG-I-like receptor signaling pathway, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRIM25 / RNF147 - H00007706-T01 from Acris Antibodies Prices $320.00 Sizes 100 µl

TRIM25 overexpression lysate - LY417532 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TRIM25 293 Cell Lysate - 408205 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TRIM25 Overexpression Lysate (Denatured) - H00007706-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

TRIM25 Overexpression Lysate (Native) - NBL1-17285 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

EFP (h): 293T Lysate - sc-113410 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

EFP (h2): 293T Lysate - sc-115553 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TRIM25 Over-expression Lysate Product - GWB-B02EB5 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

TRIM25 Overexpression Lysate (Denatured) - H00007706-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human TRIM25 Knockdown Stable Cell Line - CSC-DC016577 from Creative biogene Category Cell Line Species Human

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