| Gene Symbol |
TRIM25
|
| Entrez Gene |
7706
|
| Alt Symbol |
EFP, RNF147, Z147, ZNF147
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 25
|
| Other Description |
E3 ubiquitin/ISG15 ligase TRIM25|RING finger protein 147|estrogen-responsive finger protein|tripartite motif protein TRIM25|tripartite motif-containing 25|tripartite motif-containing protein 25|ubiquitin/ISG15-conjugating enzyme TRIM25|zinc finger protein 147 (estrogen-responsive finger protein)|zinc finger protein-147
|
| Swissprots |
Q14258
|
| Accessions |
EAW94523 EAW94524 EAW94525 Q14258 AB208994 BAD92231 AK024597 AK310720 BC013752 BC016924 AAH16924 BC038247 BC042541 AAH42541 BC053605 BC106889 BC106890 BC114339 BM146967 BX538220 CF121587 D21205 BAA04747 NM_005082 NP_005073
|
| Function |
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. {ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17392790}. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:15130519}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway, Influenza A
|