TRIM25

Gene Symbol	TRIM25
Entrez Gene	7706
Alt Symbol	EFP, RNF147, Z147, ZNF147
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 25
Other Description	E3 ubiquitin/ISG15 ligase TRIM25|RING finger protein 147|estrogen-responsive finger protein|tripartite motif protein TRIM25|tripartite motif-containing 25|tripartite motif-containing protein 25|ubiquitin/ISG15-conjugating enzyme TRIM25|zinc finger protein 147 (estrogen-responsive finger protein)|zinc finger protein-147
Swissprots	Q14258
Accessions	EAW94523 EAW94524 EAW94525 Q14258 AB208994 BAD92231 AK024597 AK310720 BC013752 BC016924 AAH16924 BC038247 BC042541 AAH42541 BC053605 BC106889 BC106890 BC114339 BM146967 BX538220 CF121587 D21205 BAA04747 NM_005082 NP_005073
Function	Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. {ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17392790}. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:15130519}.
Top Pathways	RIG-I-like receptor signaling pathway, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRIM25 full length protein - ab152814 from Abcam Category Protein Source Wheat germ Species Human

Human TRIM25 protein fragment - ab152815 from Abcam Category Protein Source Wheat germ Species Human

TRIM25 Antibody Blocking Peptide - LS-E4523 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM25 Antibody Blocking Peptide - LS-E11905 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM25 Antibody Blocking Peptide - LS-E21261 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM25 Antibody Blocking Peptide - LS-E21262 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM25 Antibody Blocking Peptide - LS-E30384 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRIM25 Antibody Blocking Peptide - LS-E30385 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TRIM25 Protein - H00007706-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRIM25 Partial Recombinant Protein - H00007706-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRIM25 Blocking Peptide - NBP1-76825PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TRIM25 Blocking Peptide - NBP1-76826PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TRIM25-Antibody-Center-Blocking-Peptide - BP16857c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRIM25 / RNF147 - H00007706-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TRIM25 / RNF147 - H00007706-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TRIM25 / RNF147 - H00007706-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRIM25 / RNF147 - H00007706-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRIM25 / RNF147 Control Peptide - AP30946CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TRIM25 / RNF147 Control Peptide - AP30947CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TRIM25 Peptide - 4315P from ProSci Category Peptide Species Human

TRIM25 Peptide - 4317P from ProSci Category Peptide Species Human

TRIM25 fusion protein - ag3241 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

EFP (D222) Peptide - BS2058P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human E3 ubiquitin/ISG15 ligase TRIM25(TRIM25) - CSB-YP617909HU CSB-EP617909HU CSB-BP617909HU CSB-MP617909HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TRIM25 / RNF147 - TP303757 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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