TRIM25

Gene Symbol TRIM25
Entrez Gene 7706
Alt Symbol EFP, RNF147, Z147, ZNF147
Species Human
Gene Type protein-coding
Description tripartite motif containing 25
Other Description E3 ubiquitin/ISG15 ligase TRIM25|RING finger protein 147|estrogen-responsive finger protein|tripartite motif protein TRIM25|tripartite motif-containing 25|tripartite motif-containing protein 25|ubiquitin/ISG15-conjugating enzyme TRIM25|zinc finger protein 147 (estrogen-responsive finger protein)|zinc finger protein-147
Swissprots Q14258
Accessions EAW94523 EAW94524 EAW94525 Q14258 AB208994 BAD92231 AK024597 AK310720 BC013752 BC016924 AAH16924 BC038247 BC042541 AAH42541 BC053605 BC106889 BC106890 BC114339 BM146967 BX538220 CF121587 D21205 BAA04747 NM_005082 NP_005073
Function Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. {ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17392790}. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:15130519}.
Top Pathways RIG-I-like receptor signaling pathway, Influenza A

EFP CRISPR/Cas9 KO Plasmid (h) - sc-402678 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EFP HDR Plasmid (h) - sc-402678-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EFP Double Nickase Plasmid (h) - sc-402678-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EFP Double Nickase Plasmid (h2) - sc-402678-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EFP CRISPR Activation Plasmid (h) - sc-402678-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EFP CRISPR Activation Plasmid (h2) - sc-402678-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EFP Lentiviral Activation Particles (h) - sc-402678-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EFP Lentiviral Activation Particles (h2) - sc-402678-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EFP siRNA (h) - sc-37825 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EFP shRNA Plasmid (h) - sc-37825-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EFP shRNA (h) Lentiviral Particles - sc-37825-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIM25 RNAi - H00007706-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU005761 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21964 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21964 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TRIM25 siRNA (Human) - CRH5224 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRIM25 - MBS8218223 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TRIM25 (NM_005082.4) - SHH434508 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human TRIM25(NM_005082.4) - SHL094008 from Creative biogene

Category siRNA
Species Reactivities Human

Human TRIM25 siRNA - orb265726 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRIM25 shRNA Plasmid (Human) - CHH5224 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TRIM25 miRNA 3'UTR clone - MiUTR4H-TG09351 from Creative biogene

Species Reactivities Human
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