| Gene Symbol | PNC1 |
|---|---|
| Entrez Gene | 852846 |
| Alt Symbol | - |
| Species | Yeast |
| Gene Type | protein-coding |
| Description | nicotinamidase |
| Other Description | - |
| Swissprots | D6VUA2 P53184 |
| Accessions | DAA08063 P53184 NM_001180902 NP_011478 |
| Function | Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate. {ECO:0000269|PubMed:11816029, ECO:0000269|PubMed:12736687, ECO:0000269|PubMed:14729974}. |
| Subcellular Location | Cytoplasm. Nucleus. Peroxisome. Note=Concentrates in peroxisomes. |
| Top Pathways | Nicotinate and nicotinamide metabolism |