| Gene Symbol |
PPM1L
|
| Entrez Gene |
151742
|
| Alt Symbol |
PP2C-epsilon, PP2CE, PPM1-LIKE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase, Mg2+/Mn2+ dependent, 1L
|
| Other Description |
PP2C epsilon|Protein phosphatase 2C epsilon isoform|protein phosphatase 1L|protein phosphatase 2C isoform epsilon
|
| Swissprots |
Q96NM7 Q2M3J2 Q5SGD2
|
| Accessions |
EAW78626 Q5SGD2 AK055115 BAB70856 AK055323 AK055510 AK092378 AY337264 AAR00269 BC035116 BC090872 BC104885 AAI04886 BC104887 AAI04888 BC110801 XM_006713507 XP_006713570 XM_011512440 XP_011510742 XM_011512441 XP_011510743 NM_139245 NP_640338
|
| Function |
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. {ECO:0000269|PubMed:17456047}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas. {ECO:0000269|PubMed:15560375}.
|