| Gene Symbol | Il1r1 |
|---|---|
| Entrez Gene | 16177 |
| Alt Symbol | CD121a, CD121b, IL-1R1, IL-iR, Il1r-1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interleukin 1 receptor, type I |
| Other Description | CD121 antigen-like family member A|IL-1 receptor alpha chain|IL-1R-1|IL-1R-alpha|IL-1RT-1|IL-1RT1|interleukin-1 receptor alpha|interleukin-1 receptor type 1|interleukin-1 receptor type I|p80 |
| Swissprots | P13504 |
| Accessions | EDL14572 P13504 AK048550 BAC33372 AK054137 BAC35666 AK166301 BC109135 AAI09136 M20658 AAA39279 XM_006495713 XP_006495776 XM_006495714 XP_006495777 XM_006495715 XP_006495778 XM_006495716 XP_006495779 XM_006495717 XP_006495780 XM_006495718 XP_006495781 XM_006495719 XP_006495782 XM_006495720 XP_006495783 XM_006495721 XP_006495784 XM_006495722 XP_006495785 XM_006495723 XP_006495786 XM_011238436 XP_011236738 NM_001123382 NP_001116854 NM_008362 NP_032388 |
| Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000305}. Secreted {ECO:0000250}. |
| Top Pathways | Amoebiasis, Inflammatory mediator regulation of TRP channels, HTLV-I infection, Osteoclast differentiation, Cytokine-cytokine receptor interaction |