| Gene Symbol |
AURKA
|
| Entrez Gene |
6790
|
| Alt Symbol |
AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aurora kinase A
|
| Other Description |
ARK-1|Aurora-A kinase|IPL1-related kinase|aurora 2|aurora-related kinase 1|aurora/IPL1-like kinase|aurora/IPL1-related kinase 1|breast tumor-amplified kinase|breast-tumor-amplified kinase|hARK1|protein phosphatase 1, regulatory subunit 47|serine/threonine kinase 6|serine/threonine protein kinase 15|serine/threonine-protein kinase 15|serine/threonine-protein kinase 6|serine/threonine-protein kinase aurora-A
|
| Swissprots |
Q9UPG5 Q9BQD6 O14965 O75873 O60445 E1P5F9
|
| Accessions |
AAC23448 AAF29508 EAW75550 EAW75551 EAW75552 EAW75553 EAW75554 EAW75555 EAW75556 EAW75557 EAW75558 EAW75559 EAW75560 EAW75561 EAW75562 O14965 AF008551 AAC12708 AF011468 AAC63902 AK301769 BAG63228 AK312776 BAG35640 AL711075 AM392948 CAL37826 BC001280 AAH01280 BC002499 AAH02499 BC006423 AAH06423 BC027464 AAH27464 BF029182 BM458030 BQ435059 BU171303 BU542363 CB113289 CB138172 D84212 BAA23592 DQ891270 ABM82196 DQ894458 ABM85384 XM_005260534 XP_005260591 XM_006723872 XP_006723935 XM_011529021 XP_011527323 NM_003600 NP_003591 NM_198433 NP_940835 NM_198434 NP_940836 NM_198435 NP_940837 NM_198436 NP_940838 NM_198437 NP_940839
|
| Function |
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cel
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Colocalized with SIRT2 at centrosome. Moves to the midbody during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
|
| Top Pathways |
Oocyte meiosis
|
