| Gene Symbol | Gprc6a |
|---|---|
| Entrez Gene | 294394 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | G protein-coupled receptor, class C, group 6, member A |
| Other Description | G protein-coupled receptor, family C, group 6, member A|G-protein coupled receptor family C group 6 member A |
| Swissprots | Q70VB1 |
| Accessions | EDL92950 Q70VB1 AJ535460 CAD59483 NM_001271106 NP_001258035 |
| Function | Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:17478059}; Multi-pass membrane protein {ECO:0000269|PubMed:17478059}. |
| Tissue Specificity | High expression in soft palate. Weak expression in kidney, liver, lung and brain. No expression detected in heart, testis, skeketal muscle amd spleen. {ECO:0000269|PubMed:17478059}. |