| Gene Symbol | HSD17B4 |
|---|---|
| Entrez Gene | 3295 |
| Alt Symbol | DBP, MFE-2, MPF-2, PRLTS1, SDR8C1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | hydroxysteroid (17-beta) dehydrogenase 4 |
| Other Description | 17-beta-HSD 4|17-beta-HSD IV|17-beta-hydroxysteroid dehydrogenase 4|17beta-estradiol dehydrogenase type IV|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase|D-3-hydroxyacyl-CoA dehydratase|D-bifunctional protein, peroxisomal|beta-hydroxyacyl dehydrogenase|beta-keto-reductase|multifunctional protein 2|peroxisomal multifunctional enzyme type 2|peroxisomal multifunctional protein 2|short chain dehydrogenase/reductase family 8C member 1|short chain dehydrogenase/reductase family 8C, member 1 |
| Swissprots | F5HE57 B4DNV1 E9PB82 P51659 B4DVS5 |
| Accessions | AAD08652 CAA72203 EAW48910 EAW48911 P51659 AK094049 BAG52804 AK293254 BAG56786 AK295440 BAG58380 AK298075 BAG60363 AK299685 BAG61592 AK301212 BAG62787 AK308968 AK312449 BAG35356 AL713635 AU105854 BC003098 AAH03098 CB067275 CX782401 DA296575 DA426062 DA508630 DC325873 DQ891866 ABM82792 DQ895055 ABM85981 X87176 CAA60643 NM_001199291 NP_001186220 NM_001292027 NP_001278956 NM_001292028 NP_001278957 NM_000414 NP_000405 NM_001199292 NP_001186221 |
| Function | Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. {ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| Subcellular Location | Peroxisome. |
| Tissue Specificity | Present in many tissues with highest concentrations in liver, heart, prostate and testis. |
| Top Pathways | Primary bile acid biosynthesis, Peroxisome |