| Gene Symbol | kdm2b |
|---|---|
| Entrez Gene | 444267 |
| Alt Symbol | fbxl10, jhdm1b |
| Species | Xenopus |
| Gene Type | protein-coding |
| Description | lysine (K)-specific demethylase 2B |
| Other Description | F-box and leucine-rich repeat protein 10|F-box/LRR-repeat protein 10|[Histone-H3]-lysine-36 demethylase 1B|jmjC domain-containing histone demethylation protein 1B|lysine-specific demethylase 2B |
| Swissprots | Q6GNT8 Q640I9 |
| Accessions | Q640I9 BC073414 AAH73414 BC082636 AAH82636 NM_001092371 NP_001085840 |
| Function | Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus, nucleolus {ECO:0000250}. |