Gene Symbol | DECR2 |
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Entrez Gene | 26063 |
Alt Symbol | PDCR, SDR17C1 |
Species | Human |
Gene Type | protein-coding |
Description | 2,4-dienoyl CoA reductase 2, peroxisomal |
Other Description | 2,4-dienoyl-CoA reductase 2|peroxisomal 2,4-dienoyl-CoA reductase|short chain dehydrogenase/reductase family 17C member 1|short chain dehydrogenase/reductase family 17C, member 1 |
Swissprots | Q6ZRS7 Q96ET0 Q9NUI1 |
Accessions | AAK61231 EAW85811 EAW85812 EAW85813 EAW85814 EAW85815 EAW85816 Q9NUI1 AJ293009 CAC05664 AK055839 AK094340 AK128012 BAC87232 AK225961 AL442076 CAC09442 BC010740 AAH10740 BC011968 AAH11968 BC030226 HQ447148 ADQ31635 NM_020664 NP_065715 |
Function | Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19- docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. |
Subcellular Location | Peroxisome {ECO:0000250}. |
Top Pathways | Peroxisome |
DECR2 CRISPR/Cas9 KO Plasmid (h) - sc-408672 from Santa Cruz Biotechnology
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DECR2 HDR Plasmid (h) - sc-408672-HDR from Santa Cruz Biotechnology
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DECR2 Double Nickase Plasmid (h) - sc-408672-NIC from Santa Cruz Biotechnology
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DECR2 Double Nickase Plasmid (h2) - sc-408672-NIC-2 from Santa Cruz Biotechnology
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DECR2 CRISPR Activation Plasmid (h) - sc-408672-ACT from Santa Cruz Biotechnology
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DECR2 CRISPR Activation Plasmid (h2) - sc-408672-ACT-2 from Santa Cruz Biotechnology
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DECR2 Lentiviral Activation Particles (h) - sc-408672-LAC from Santa Cruz Biotechnology
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DECR2 Lentiviral Activation Particles (h2) - sc-408672-LAC-2 from Santa Cruz Biotechnology
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DECR2 siRNA (h) - sc-93455 from Santa Cruz Biotechnology
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DECR2 shRNA Plasmid (h) - sc-93455-SH from Santa Cruz Biotechnology
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DECR2 shRNA (h) Lentiviral Particles - sc-93455-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN7078 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7078 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04327 from Sigma-Aldrich
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DECR2 siRNA (Human) - CRH8691 from Cohesion Biosciences
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DECR2 - MBS8219049 from MyBioSource
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shRNA set against Human DECR2 (NM_020664.3) - SHH276273 from Creative biogene
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shRNA set against Human DECR2(NM_020664.3) - SHG227791 from Creative biogene
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Human DECR2 siRNA - orb269193 from Biorbyt
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DECR2 shRNA Plasmid (Human) - CHH8691 from Cohesion Biosciences
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DECR2 miRNA 3'UTR clone - MiUTR1H-02748 from Creative biogene
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